252130 IPrEX Study Methodology and Results

Tuesday, November 1, 2011: 2:30 PM

Kenneth Mayer, MD , The Fenway Institute, Fenway Health, Boston, MA
Men who have sex with men remain the largest segment of the US population at risk for HIV infection. Despite expanded HIV testing, community-based behavioral interventions to reduce risk behaviors, promotion of condom use, increased detection and treatment of other sexually transmitted diseases such as syphilis, gonorrhea and chlamydia, and mental health counseling to address substance abuse, new HIV infections among MSM have continued to increase since the mid-1990s. Pre-exposure prophylaxis (PrEP) is a unique approach to HIV prevention in which antiretroviral drugs are used by HIV-uninfected individuals prior to a potential HIV exposure. PrEP is distinct from post-exposure prophylaxis (PEP), where an individual takes ARV medication promptly after a possible HIV exposure to avoid infection. The Pre-Exposure Prophylaxis Initiative (iPrEX), an international, randomized, double-blind, placebo-controlled phase III clinical trial was conducted to evaluate the efficacy of daily oral use of TDF (tenofovir disoproxil fumarate) and FTC (emtricitabine) among 2,499 HIV-uninfected men and 29 transgendered men who reported engaging in high-risk sexual behaviors with other men within the preceding 6 months. Results of this trial were published in the New England Journal of Medicine in November 2010.

Learning Areas:
Protection of the public in relation to communicable diseases including prevention or control

Learning Objectives:
Describe in full detail the iPrEX study methodology and results.

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am the Principle Investigator of the iPrEX study at Finway Health in Boston, MA.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.