254522 Shifting Age Distribution of Dengue Infection: Analysis of Data Collected in Kamphaeng Phet Province, Thailand from 1994 to 2010

Tuesday, October 30, 2012 : 12:30 PM - 12:45 PM

Derek Licina, MPH , Department of Global Health, The George Washington University, Washington, DC
Recent studies suggest the average age of dengue infection is increasing and may be due in part to a shift in dengue environmental and age distribution. Building upon initial reports, this study assessed the average age of symptomatic dengue infection in Kamphaeng Phet Province, Thailand from 1994 and 2010. A pooled cross-sectional dataset developed by the Armed Forces Research Institute of Medical Sciences (AFRIMS) located in Bangkok, Thailand was used for the analysis. The dataset consisted of 6,240 serum samples collected from patients seen at the Kamphaeng Phet Province Hospital from 1994 to 2010. A dramatic shift in the average age of patients testing positive for dengue infection was documented from 8.6 to 17.0 years of age between years 1994 and 2010. Significant differences were also found between consecutive years and distinct year groups. The results of this study are the first to document an increase in dengue age incidence using laboratory confirmation over a 17 year period of time in Thailand. This evidence has implications for the dengue vaccine development and implementation process and clinical practice guidelines for both diagnosis and treatment as the age of infection increases.

Learning Areas:
Clinical medicine applied in public health
Public health or related research

Learning Objectives:
1. Demonstrate an understanding of the disease burden associated with dengue infection at the global, regional, and national level using Thailand as a case study. 2. Explain current hypotheses regarding the change in traditional dengue disease pattern. 3. Discuss the age shift among patients testing positive for dengue infection in Kamphaeng Phet Province, Thailand. 4. Describe the potential implications of the increased age of dengue infection.

Keywords: Disease Data, Public Health Research

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I have presented at both national and international conferences and published in peer reviewed journals on various topics related to public health. This original research was conducted by me and will inform ongoing vaccine development conducted by the U.S Department of Defense, Armed Forces Research Institute of Medical Sciences Bangkok in conjunction with the Thailand Ministry of Public Health.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.