255335 No association between 25-hydroxyvitamin D (25(OH)D) and 5-year change in alveolar crestal height (ACH) among postmenopausal women participating in the Osteoporosis and Periodontal Disease Study

Sunday, October 28, 2012

Amy Millen, PhD , Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, NY
Kathleen Hovey, MS , Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, NY
Mya Swanson, BA , Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, NY
Michael LaMonte, PhD, MPH , Department of Social and Preventive Medicine, School of Public Health and Professions, State University of New York at Buffalo, Buffalo, NY
Christopher Andrews, PhD , Department of Biostatistics, University at Buffalo, The State University of New York, Buffalo, NY
Melissa Kluczynski, MS , Orthopaedics and Sports Medicine, School of Medicine and Biomedical Sciences, Buffalo, NY
Robert Genco, PhD, DDS , Department of Oral Biology, State University of New York at Buffalo, Buffalo, NY
Jean Wactawski-Wende, PhD , Department of Social and Preventive Medicine, School of Public Health and Professions, State University of New York at Buffalo, Buffalo, NY
Background: Vitamin D is hypothesized to prevent alveolar bone loss due to its anti-inflammatory properties and its role in maintaining adequate systemic calcium concentrations. To our knowledge, no study has prospectively investigated associations between vitamin D status, assessed with 25(OH)D concentrations, and change in ACH.

Purpose: We investigated associations between plasma 25(OH)D concentrations (assessed 1997-2000) and 5-year change in ACH assessed using intraoral radiographs (1997-2000 to 2002-2005) among 691 postmenopausal women in an ancillary study of the Women's Health Initiative.

Methods: Three measures of ACH change (mm) (negative values represent loss in ACH) were used: 1) whole-mouth mean change (WMC), 2) whole-mouth mean of side-by-side change per site (SSC), and 3) site with greatest loss (SGL). Linear regression was used to estimate beta-coefficients (â), standard errors (SE), and p-values corresponding to change in ACH for a 10 nmol/L increase in 25(OH)D. Models were adjusted for age, education, waist circumference, smoking status, dental visits, physical activity, and use of hormone therapy, bone drugs, or selective estrogen receptor modulators.

Results: There was minimal change in ACH over time (WMC mean±SE = -0.25±0.02). No association was observed between 25(OH)D and WMC, SSC, or SGL (â±SE (p-value)=0.002±0.01 (0.85), 0.001±0.004 (0.80), and 0.01±0.02 (0.53), respectively). Associations were not modified by age, baseline periodontal disease status, smoking status, body mass index, hormone therapy use, bone drug use, or osteoporosis status.

Conclusion: No evidence of an association between 25(OH)D and 5-year change in ACH was observed. Null associations may be explained by the minimal change in ACH.

Learning Areas:
Chronic disease management and prevention
Epidemiology

Learning Objectives:
1. Analyze the prospective association between vitamin D status, assessed with plasma 25-hydroxyvitamin D (25(OH)D), and change in alveolar crestal height over a 5 year period in postmenopausal women. 2. Describe the 5 year change in measures of alveolar crestal height among postmenopausal women.

Keywords: Epidemiology, Oral Health

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am qualified to be an abstract Author on the role of vitamin D in periodontal disease as I have a federally funded R21 grant to investigate associations between vitamin D status and periodontal disease in a cohort of postmenopausal women.
Any relevant financial relationships? Yes

Name of Organization Clinical/Research Area Type of relationship
Mushroom Council The effect of vitamin D rich mushrooms on functional performance and quality of life in older men and women Co-Investigator on a grant (in the noted research area) funded by the Mushroom Councili.

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.

Back to: 2087.0: Oral Health Trends: Epidemiology, Disparities, and Special Needs Populations