258134 Maternal pre-pregnancy BMI, gestational weight gain, and age at menarche in daughters

Tuesday, October 30, 2012

Rachel Berry-Millett , Health and Medical Sciences, UC Berkeley-UCSF Joint Medical Program, Berkeley, CA
Julie Deardorff, PhD , Community Health and Human Development Division, School of Public Health, University of California, Berkeley, Berkeley, CA
David Rehkopf, ScD, MPH , Division of General Medical Disciplines, Stanford University School of Medicine, Stanford, CA
Maureen Lahiff, PhD , School of Public Health, University of California, Berkeley, Berkeley, CA
Barbara Abrams, DrPH, RD , Division of Epidemiology, School of PUblic Health, Berkeley, CA
Objectives: Low birth weight, rapid postnatal growth, and high childhood BMI are associated with earlier menarche in girls. Associations between maternal pregnancy experience and daughters' age at menarche are less understood. In this study, we examine whether maternal pre-pregnancy BMI and gestational weight gain are related to the timing of menarche in daughters. Methods: The sample includes 2,181 mother-daughter pairs from the 1979 National Longitudinal Survey of Youth, a prospective cohort study. Survival analysis with Cox proportional hazards was used to estimate whether maternal pre-pregnancy overweight and obesity (BMI≥25.0 kg/m2) and gestational weight gain adequacy (categorized as inadequate, recommended, and excessive based on 2009 Institute of Medicine guidelines) were associated with risk of earlier menarche among girls, controlling for important covariates. Results: Maternal pre-pregnancy overweight and obesity were associated with daughters' earlier menarche (HR= 1.20, 95% CI 1.05-1.38). Excess gestational weight gain was not associated with daughters' age at menarche (HR=1.10, 95% CI 0.97, 1.25) in the adjusted model, nor was inadequate gestational weight gain (HR=1.05, 95% CI 0.92, 1.19). Consistent with past literature, earlier maternal age at menarche, Hispanic and black race, and lower parental education were all associated with an increased risk of earlier menarche in daughters. Conclusions: Maternal pre-pregnancy overweight and obesity is associated with an earlier menarcheal age in offspring. Further research is warranted to elucidate the pathways through which this relationship may operate. Gestational weight gain adequacy was not associated with menarcheal timing in this study after controlling for key covariates.

Learning Areas:
Advocacy for health and health education

Learning Objectives:
1. Assess whether maternal factors - including pre-pregnancy BMI and gestational weight gain - are associated with the timing of menarche in daughters

Keywords: Maternal and Child Health, Adolescent Health

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am a third year medical student in the UC Berkeley-UCSF Joint Medical Program. I have a strong research background in primary care and health care access. My Master's Thesis in Health and Medical Sciences has focused on studying the determinants of menarcheal timing in girls, including a comprehensive review of the literature.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.