259988 Low birth weight is associated with insulin and homeostasis model assessment of insulin resistance but not with glucose and glycated haemoglobin A (1c) in asymptomatic younger adults: The Bogalusa Heart Study

Tuesday, October 30, 2012

Azad R. Bhuiyan, MD, PhD , Department of Epidemiology, Jackson State University, Jackson, MS
Sathanur Srinivasan, PhD , Epidemiology, Tulane University, New Orleans, LA
Wei Chen, MD, PhD , Epidemiology, Tulane University, New Orleans, LA
Camilo Fernandez, MD, MS , Epidemiology, Tulane University, New Olreans, LA
Mario Azevedo, MPH, PhD , Epidemiology, Jackson State University, Jackson, MS
Gerald Berenson, MD , Epidemiology, Tulane University, New Orleans, LA
Background: Low birth weight, an indictor of intrauterine growth restriction is associated with cardiovascular (CV) disease and type 2 diabetes. Measures of glucose homeostasis such as insulin, glucose, glycated haemoglobin (HbA(1c)) and homeostasis model assessment of insulin resistance (HOMA-IR) are also recognized as risk factors of CV disease and type 2 diabetes. However, information linking low birth weight with insulin, glucose, HbA (1c) and HOMA-IR in a biracial (black/white) population is scant.

Methods: This aspect was examined in a cohort of 784 black and white subjects (28 % black, 42 % male) aged 24-43 years (mean 36.1 years) enrolled in the Bogalusa Heart Study. Birth weight and gestational age data were retrieved from Louisiana State Public Health Office.

Results: Blacks vs whites had significantly lower birth weight (3.149 kg vs 3.436 kg, p< 0.0001) and higher levels of insulin, HbA(1c) and HOMA-IR (14.012 žU/ml vs 11.622 žU/ml, p=0.004, 8.16 mmol/L vs 5.82 mmol/L p<0.0001 and 3.12 vs 2.52, p=0.004 respectively). In a multivariate stepwise regression model, adjusting for race, sex, age, BMI, mean arterial blood pressure, triglyceride-HDL cholesterol ratio and smoking status, low birth weight was retained as an independent predictor variable for higher insulin levels (p=0.0003) and HOMA-IR (p=0.0009) but not for glucose and HbA(1c) levels.

Conclusions: The observed deleterious effect of low birth weight on glucose homeostasis depicted by insulin level and HOMA-IR in asymptomatic younger adults may potentially link fetal growth retardation and CV disease and type 2 diabetes, which has important health implications.

Learning Areas:
Advocacy for health and health education
Chronic disease management and prevention
Epidemiology

Learning Objectives:
The purpose of this study is to examine the relationship between low birth weight and measures of glucose homeostasis in biracial semirural population.

Keywords: Birth Outcomes, Chronic (CVD)

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am a faculty at college of public health service in Jackson State University. I am qualified to be an abstract author on this presentation.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.