260025 Determinants of coronary artery calcium score for early identification and prevention of coronary artery disease among asymptomatic adults

Monday, October 29, 2012 : 4:30 PM - 4:50 PM

Sreenivas P. Veeranki, MBBS, DrPH, MPH , Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN
Hadii M. Mamudu, PhD, MPA , Department of Health Services Management and Policy, College of Public Health, East Tennessee State University, Johnson City, TN
Yi He, MPH , Department of Biostatistics and Epidemiology, East Tennessee State University, Johnson City, TN
Yang Chen, MS , Department of Biostatistics and Epidemiology, East Tennessee State University - College of Public Health, Johnson City, TN
Rafie Boghozian-Khoygani, MBA , Department of Economics and Finance, East Tennessee State University- College of Business and Technology, Johnson City, TN
Non-communicable diseases, including Coronary Artery Disease (CAD) are leading preventable cause of death worldwide, demanding early detection, especially among asymptomatic individuals. Coronary Artery Calcium (CAC) score quantified using 64-slice multidetector computed tomography is a noninvasive radiological test for screening and identifying individuals at risk for CAD. In this study, we collected data related to individuals' socioeconomic and demographic characteristics, risk factors and respective CAC scores from three tertiary cardiovascular institutes in the U.S. during 2011. The data was analyzed for descriptive and inferential statistics. Univariate, bivariate and chi-square statistics were reported. A multivariate logistic regression analysis using socio-ecological theoretical approach was used to delineate the key determinants of CAC score among these individuals. Preliminary results using 503 individuals indicated that 56% were at high risk for CAD; 48% hypertensive; 18% diabetic; 30% obese; and 59% hypercholesterolemic. Males were at very high risk [AOR 16.60; 95% CI (5.98- 22.06); p-value <0.001] compared to females. Compared to never smokers, current smokers are at high risk [AOR 8.41; 95% CI (2.30- 10.83); p-value 0.001] for CAD. Similarly, asymptomatic obese individuals [AOR 3.85; 95% CI (1.41 - 8.52); p-value 0.01] were significantly associated with very high CAC scores compared to non-obese. Understanding key determinants of individual CAC score will not only help physicians and public health professionals to tailor treatment and intervention approaches to slow or stop the progression of disease but also encourage people for CAC score screening to prevent the onset of CAD and save future treatment costs.

Learning Areas:
Chronic disease management and prevention
Clinical medicine applied in public health
Public health or related research
Social and behavioral sciences

Learning Objectives:
1) To analyze the risk for Coronary Artery Disease among asymptomatic individuals. 2) To identify asymptomatic individuals with high and very high Coronary Artery Calcium Scores. 3) To ascertain the key socioeconomic and demographic determinants of Coronary Artery Calcium Score for early identification of individuals at risk for Coronary Artery Disease.

Keywords: Chronic (CVD), Epidemiology

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am responsible for conceptualizing the research idea, design and conduction of this research study, which makes me qualified be an abstract author and present the study at the conference.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.