261147 Age specific risk of subsequent end stage renal disease for patients with diabetes

Tuesday, October 30, 2012 : 8:50 AM - 9:05 AM

Fung-Chang Sung, PhD , Department of Public Health, China Medical University, Taichung, Taiwan
Ya-Fei Yang, MD , Department of Public Health, China Medical University, Taichung, Taiwan
Chih-Hsin Mou, MSPH , Department of Public Health, China Medical University, Taichung, Taiwan
Pei-Chun Chen, PhD , Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
Chiu-Chin Huang, MD , Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
Objectives. Study on age-specific association between diabetes mellitus (DM) and the risk of developing end stage renal disease (ESRD) is limited. This study evaluated the age-specific risk differences of developing ESRD for patients with DM. Methods. This study used Taiwan National Health Insurance claims data of 1996-2009 to identify 26,351 patients with DM newly diagnosed in 1997-2000. From insured population without DM, we randomly selected 105,404 persons frequency matched with sex, age and the year of DM patient selected. Incidence of ESRD was estimated by age-specific subcohort (<30, 30-39, 40-49, 50-59 and 60 and above years) until the follow-up end by the end of 2009. DM to non-DM cohort rate ratio was also measured for each age stratum. Results. The incidence of ESRD increased with age, from 15.6 per 1,000 person-years for < 30 years subcohort to 32.7 per 1,000 person-years for 60 years and above subcohort. The corresponding incidence for non-DM sucohorts increased from 0.9 per 1,000 person-years to 12.0 per 1,000 person-years. The age-specific DM to non-DM subcohort rate ratio decreased from 16.7 for the <30-year stratum to 2.7 for the 60 and above stratum (p for trend <0.001). However, the multivariable Cox model measured hazard ratio increased with age after controlling for covariates. Conclusions. The age-specific relative risk of developing ESRD for DM patients is particularly greater for younger patients than for older patients. It is critical to begin DM prevention for young patients. Key words Diabetes mellitus, end stage renal disease.

Learning Areas:
Basic medical science applied in public health
Chronic disease management and prevention
Clinical medicine applied in public health
Epidemiology
Public health or related research

Learning Objectives:
Demonstrate that young patients with diabetes have higher relative risk of developing end stage renal disease than old patients with diabetes, compared with non-diabetes individuals.

Keywords: Diabetes, Taiwan Health

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: received my MS training in Environmental Health and PhD in Epidemiology at University of Washington, Seattle with the background of Pharmacy and Public Health in Taiwan. I had faculty positions at Morehouse School of Medicine and National Taiwan University previously. Curretly, I am a professor at China Medical University Department of Public Health, Taiwan. My research works have concentrated in Epidemiology in CVD, cancer, kidney disease and Enivronmental Epidemiology, with about 200 papers published.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.

Back to: 4028.0: Diabetes Epidemiology