261431 Vitamin D deficiency, insufficiency and pulse pressure

Wednesday, October 31, 2012 : 8:35 AM - 8:50 AM

Xuefeng Liu, PhD , Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN
Kesheng Wang , Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN
Dennis Tsilimingras, MD, MPH , Department of Family Medicine, College of Medicine, Florida State University, Tallahassee, FL
Background: Suboptimal vitamin D remains common and increases the risk of many chronic illnesses, including infectious diseases, cardiovascular disease and common cancers. However, the relationship between suboptimal vitamin D and the risk of increased pulse pressure associated with cardiovascular events has not been well characterized.

Methods: Cross-sectional data of 15,296 participants aged 18 years or older were collected from the 2001-2006 National Health and Nutrition Examination Survey (mean age 46 years; 50% women; 72% white, 12% Hispanic and 11% black). The regression coefficients of pulse pressure across levels of serum 25(OH)D (>30, 20-30 and <20 ng/ml) were estimated by conducting weighted multiple regression analyses. The adjusted odds ratios with 95% confidence intervals for abnormal pulse pressure were estimated using the weighted log-binomial method.

Results: After adjustment for potential confounding factors, participants with vitamin D deficiency are 75% (odds ratio [OR]: 1.75; 95% confidence interval [CI]: 1.37-2.23) more likely to have a pulse pressure ≥60 mmHg than those with normal vitamin D. Average pulse pressure increased by 2.25 mmHg (95% CI: 1.17-3.33) for vitamin D deficiency relative to normal levels. Vitamin D insufficiency increased continuous pulse pressure by 0.95 mmHg (95% CI: 0.21-1.69) compared with normal vitamin D levels. The risk of hypertension increased by 68% (OR: 1.68; 95% CI: 1.24-2.28) for vitamin D deficiency and 23% (OR: 1.23; 95% CI: 1.02-1.48) for vitamin D insufficiency.

Conclusion: Vitamin D deficiency and insufficiency are associated with pulse pressure and with the risk of abnormally high pulse pressure although causal effects remain to be investigated.

Learning Areas:
Chronic disease management and prevention

Learning Objectives:
1) Evaluate the association between suboptimal surum vitamin D and the risk of high pulse pressure; 2) Explain how vitamin D deficiency and insufficiency raise pulse pressure, which is a major risk factor for cardiovascular events.

Keywords: Vitamins, Hypertension

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I have been co-principal of multiple federally funded grants focusing on the epidemiology of cardiovascular disease, disease prevention and health promotion. Among my scientific interests has been the development of strategies for preventing cardiovascular envents. Several manuscripts in this area have been published or submitted and more projects are in progress.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.

Back to: 5051.0: Cardiovascular Disease