262576 Is there fat in the gap? A meta- analysis of the contribution of adiposity to racial disparities in prostate cancer

Monday, October 29, 2012 : 8:50 AM - 9:10 AM

Iman Martin, MPH, MS, PhDc , Institute of Human Genetics, University of Illinois at Chicago School of Public Health, Chicago, IL
Jocelyn R. Wilder, MPH , Health Studies Department, University of Chicago, Chicago, IL
Adam Murphy, MD , Dept. of Urology, Northwestern University, Chicago, IL
Vincent L. Freeman, MD MPH , Epidemiology, UIC School of Public Health, Chciago, IL
Background and Objective: Black men develop and die from prostate cancer (PCa) more than any other racial group. PCa incidence and mortality rates in Black men are 2.4 times that of their White (WH) counterparts. It is not clear how body composition, particularly central adiposity, contribute to racial and ethnic disparities in PCa occurrence and course. Current reviews on the adiposity relationship have tended not to adequately address this. Therefore, we conducted a systematic review and meta-analysis of the literature examining the role of adiposity in racial disparities in prostate cancer. Methods: The US National Library of Medicine National Institutes of Health PubMed database was searched for English articles published through October 1, 2012. No reviews, editorials, or comments were included in the review, although they were cited for background content. Results: Many of the available reviews on adiposity and PCa racial disparities did address occurrence and outcomes often did not present race-specific effect estimates and simply adjusted for race in multivariate models. The available evidence suggests a unique role of adiposity-related factors in the risk of PCa occurrence, progression, differences in treatment efficacy, and PCa-specific death. Lack of studies including sufficiently large numbers of AA prohibited reporting of race-specific estimates in many studies, especially in studies involving molecular biology and genetics. Conclusions: The results of this systematic review and meta-analysis highlight the need for more studies with robustly diverse samples. Our research must reflect the fact that Black men are most frequently and gravely affected by PCa.

Learning Areas:
Chronic disease management and prevention
Epidemiology

Learning Objectives:
To summarize and synthesize the current research on how body size contributes to persistent racial disparities in prostate cancer outcomes among Black men, from an epidemiologic perspective.

Keywords: African American, Cancer Prevention

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: This work was apart of my dissertation in Epidemiology from UIC; I am a PI on a federally funded health disparities grant looking at this issue.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.