263247 Asian American Community Responses to Blood Biospecimen Drives: Findings and Implications

Wednesday, October 31, 2012 : 8:50 AM - 9:10 AM

Julie Dang, MPH, CHES , Population Research & Cancer Health Disparities, University of California, Davis, Sacramento, CA
Irmgard Feldman, CCRP , Cancer Center Biorepository (CCB)/Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA
Penny Lo , Community Based Organization, Hmong Women's Heritage Association, Sacramento, CA
Christopher L. Bowlus, MD , Department of Internal Medicine, School of Medicine, University of California, Davis, Sacramento
Moon S. Chen Jr., PhD, MPH , Asian American Network for Cancer Awareness Research and Training (AANCART), University of California, Davis Cancer Center, Sacramento, CA
Background: The reluctance to contribute blood from racially diverse groups such as Asian Americans impedes the likelihood of developing personalized approaches for cancer treatment and insights that can result from understanding the molecular, biochemical, and genomic characterizations of biospecimens.

Methods: We hypothesized that through building community trust and partnerships we would be able to collect healthy blood samples from community members to serve as “healthy” referent tissue against known cases. After building trust, we hosted blood drives in the Hmong, Chinese and Vietnamese communities. Results: We collected 662 biospecimens from 184 community participants. Blood samples were tested for HBsAg and for hemoglobin A1c, both independent risk factors for liver cancer. Fifteen of the 184 subjects tested positive for the Hepatitis B. Seven of 97 subjects were considered diabetic and 25 showed high levels of glucose indicating an increased risk for diabetes.

Conclusions: The positive response from our novel community approach demonstrated (1) the willingness of Asian Americans in non-clinical settings to contribute blood for cancer research when approached properly; (2) previously undetected disease risks that documents “invisible” health risks from English-limited Asians; and (3) the value of earning the community's trust. While admittedly convenience samples, our community experience led us to pursue comparative studies of known HBsAg positive Asian patients as part of a larger study to study the progression of HBV infection to hepatocellular cancer (HCC) through examining RNA sequencing to ascertain expression levels and cataloguing the SNP variants between HCC cases and controls.

Learning Areas:
Administer health education strategies, interventions and programs
Assessment of individual and community needs for health education
Diversity and culture
Implementation of health education strategies, interventions and programs
Planning of health education strategies, interventions, and programs
Public health or related research

Learning Objectives:
1) Explain a novel approach to recruiting Asian Americans to contribute blood biospecimens for cancer research. 2) Discuss the facilitators and barriers to recruiting Asian Americans to contribute blood biospecimens for cancer research. 3) Articulate 3 conclusions stemming from Asian Americans community responses to blood biospecimen drives.

Keywords: Asian Americans, Health Disparities

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am the administrative core director and community health educator for AANCART. I designed, conducted and implemented the studies on biospecimen contribution in Asian American communities for AANCART.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.