266419 Smoking related heart disease mortality at ages 18-44 years in a recent representative US sample

Wednesday, October 31, 2012 : 9:05 AM - 9:20 AM

Rumana Khan, PhD Candidate , Graduate group of Epidemiology, University of California, Davis, Davis, CA
Bruce Leistikow, MD, MS , Public Health Sciences, Univ California, Davis, Davis, CA
Christine Stewart, PhD , Program in International and Community Nutrition, University of California, Davis, CA, Davis, CA
Danielle Harvey, PhD , Division of Biostatistics, Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, CA
     
Background: Smoking's association with heart disease (HD) morbidity is very strong in younger adults, but association with mortality is nearly unstudied. The objective of this study was to assess the risk and burden of all HD and ischemic heart disease (IHD) mortality associated with smoking among younger adults (18-44 years) from a nationally representative U.S. sample.

Methods: Data of National Health Interview Survey (NHIS) respondents from 1997-2004 were linked to their death records through 2006. The analyses were restricted to individuals 18 to 44 years of age during follow up (n = 121,284). Cox proportional hazard ratios (HR) were estimated with necessary adjustment for sample weights and design effects. Attributable fractions (AF) of smoking were calculated.

Results: After controlling for age, hypertension, diabetes, body mass index and physical activity, smoking related IHD mortality HR was 14.6 [95% confidence interval or CI, 3.3-64.9]) for female and 3.6 [95% CI, 1.2-10.4] for male. The HR for all HD mortality was 3.1 [95% CI, 1.3-7.6]) for female and 2.4 [95% CI, 1.2-4.7]) for male. The crude AF of smoking for IHD deaths for female and male were 0.58 and 0.54 respectively. The AF for all HD mortality was 0.31 for male and 0.32 for female.

Discussion: Smoking related HD mortality was high, especially in females and for IHD even after adjustment for multiple risk factors and without addressing second hand smoking.

Learning Areas:
Advocacy for health and health education
Chronic disease management and prevention
Epidemiology

Learning Objectives:
Assess the risk and burden of heart disease and ischemic heart disease mortality associated with smoking among younger adults (18-44 years)

Keywords: Heart Disease, Smoking

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am a PhD candidate in Epidemiology at University of California, Davis. I have been involved in several research projects and manuscript writing.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.

Back to: 5051.0: Cardiovascular Disease