267637 Dietary phytoestrogen consumption and urinary concentrations among Mexican women

Monday, October 29, 2012

Graciela Caire-Juvera, PhD, MPH , Public Nutrition and Health Department, Centro de Investigación en Alimentación y Desarrollo (Center for Research on Food and Development), Hermosillo, Mexico
Karina M. Chávez-Suárez, MSc , Public Nutrition and Health Department, Centro de Investigación en Alimentación y Desarrollo (Center for Research on Food and Development), Hermosillo, Mexico
Ana Isabel Valenzuela-Quintanar, PhD , Food Sciences Department, Centro de Investigación en Alimentación y Desarrollo (Center for Research on Food and Development), Hermosillo, Mexico
Isabel Ortega-Vélez, PhD , Public Nutrition and Health Department, Centro de Investigación en Alimentación y Desarrollo (Center for Research on Food and Development), Hermosillo, Mexico
Melissa M. Campa-Siqueiros, MSc , Public Nutrition and Health Department, Centro de Investigación en Alimentación y Desarrollo (Center for Research on Food and Development), Hermosillo, Mexico
Susana A. Palma-Durán, MSc , Food Sciences Department, Centro de Investigación en Alimentación y Desarrollo (Center for Research on Food and Development), Hermosillo, Mexico
Socorro Saucedo-Tamayo, MPH , Public Nutrition and Health Department, Centro de Investigación en Alimentación y Desarrollo (Center for Research on Food and Development), Hermosillo, Mexico
Lourdes Gutiérrez-Coronado, MSc , Food Sciences Department, Centro de Investigación en Alimentación y Desarrollo (Center for Research on Food and Development), Hermosillo, Mexico
María del Refugio Robles-Burgueño, MSc , Food Sciences Department, Centro de Investigación en Alimentación y Desarrollo (Center for Research on Food and Development), Hermosillo, Mexico
Julián Esparza-Romero, PhD , Public Nutrition and Health Department, Centro de Investigación en Alimentación y Desarrollo (Center for Research on Food and Development), Hermosillo, Mexico
Patricia Grajeda-Cota, BS , Food Sciences Department, Centro de Investigación en Alimentación y Desarrollo (Center for Research on Food and Development), Hermosillo, Mexico
Diana L. Luna-Parra, BS , Public Nutrition and Health Department, Centro de Investigación en Alimentación y Desarrollo (Center for Research on Food and Development), Hermosillo, Mexico
Marcia Galván-Portillo, PhD , Center for Research in Population Health, Instituto Nacional de Salud Pública (National Institute of Public Health), Cuernavaca, Mexico
Background: Consumption of foods rich in phytoestrogens is associated with significantly reduced risk for cancer, osteoporosis, and cardiovascular disease. Increased recognition of the potential health benefits of phytoestrogens has heightened the need for an instrument that can estimate exposure to phytoestrogens in epidemiological studies. Objective: To evaluate the correlation between dietary intakes of phytoestrogens estimated by a food frequency questionnaire (FFQ) and a 24h recall with their respective urinary concentrations in Mexican adult women.

Research Design and Methods: Participants were 100 Mexican women aged 25 to 60 years. Dietary intake of phytoestrogens were estimated by a 24h recall (recent intake), and a 162-item interviewer-administered FFQ (habitual intake). Sixteen phytoestrogen concentrations were measured in 12-hour urine samples by high-performance liquid chromatography-mass spectrometry (HPLC–MS). Correlations between dietary intake (FFQ and 24h recall) and urinary metabolite values were assessed using Pearson correlation coefficients.

Results: Geometric means of isoflavone, lignan and total phytoestrogen (isoflavones+lignans+flavonoids+resveratrol+coumestrol) recent intakes were 240, 138, and 7387 ug/day, respectively. Urinary concentrations of isoflavones, lignans and total phytoestrogens were 98.9, 48.7 and 336.2 ug/L, respectively. Recent isoflavone, lignan and total phytoestrogen intakes were correlated with urinary excretion of metabolites (r=0.46, p=0.0001; r=0.55, p=0.0000; r=0.41, p=0.0007, respectively). Urinary excretion of total phytoestrogens and resveratrol were also correlated with habitual intakes (r=0.73, p=0.0000; r=0.34, p=0.005, respectively).

Conclusions: Our results support the use of the 24-hour recall as a measure of dietary isoflavone, lignan and total phytoestrogens recent intake and the use of the FFQ as a measure of habitual total phytoestrogen intake in epidemiological studies.

Learning Areas:
Epidemiology
Public health or related research

Learning Objectives:
1. Identify dietary intake and excretion of phytoestrogens among Mexican women. 2. Discuss the relation between dietary intakes and urinary concentrations of phytoestrogens 3. Evaluate the importance of this topic for public health, women’s health, epidemiology and nutrition research and applications.

Keywords: Women's Health, Nutrition

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: This research is part of a project at CIAD (Center for Research on Food and Development) in which I am the responsible researcher.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.

Back to: 3088.0: Women and Children's Health Poster Session