271256 Behavioral inhibition system (BIS) and gene-environment factors associated with African-American smoking behaviors

Sunday, October 28, 2012

Araceli Gutierrez, SM 2014, Harvard School of Public Health , SOAR-Health Program, Howard University College of Medicine, Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS); Howard University Cancer Center (HUCC), Washington, DC
Carla D. Williams, PhD , Howard University Cancer Center, Washington, DC
Mary A. Garza, PhD, MPH , Behavioral and Community Health, University of Maryland for Health Equity School of Public Health, University of Maryland College Park, College Park, MD
Shondelle M. Wilson-Frederick, PhD , Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
Benedict Arrey, PhD , Department of Pharmaceutical Sciences, Howard University and College of Pharmacy, Washington, DC
Jean G. Ford, MD , Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
Purpose: Socio-economic status (SES) is highly correlated with cancer rates and people of lower SES are more likely to engage in behaviors that increase cancer risk, such as tobacco use. Genetic predisposition to Nicotine Dependence (ND) has been linked to the dopamine receptor D2 (DRD2) gene and the Taq1 A single nucleotide polymorphism (SNP) minor allele of the dopamine receptor, specifically rs1800497, which is more prevalent in African-Americans (AA). Although dopamine has been linked to the Behavioral Activation System (BAS) and is involved in multiple addictive disorders, study findings indicate higher Behavioral Inhibition System (BIS) scores among heavier smokers. This study examines the contributions to and associations between environmental socio-demographic and exposure variables, the BIS harm avoidance personality trait and rs1800497 on smoking behaviors in African-American smokers. Methods: A cross-sectional sample of 389 AA smokers from Baltimore, Maryland and Washington, D.C. responded to study questionnaires and donated blood samples for genetic analysis. Data from study questionnaires were merged and analyzed to compare and examine differences among current smokers by mean BIS scores, environmental socio-demographic and exposure variables, cigarettes smoked per day, number of smoking cessation attempts and rs1800497 personality alleles. A 1-way ANOVA and Post-Hoc Least Significance Test (LSD) were used to examine the associations between the alleles for rs1800497 and mean BIS scores. Results: An association was noted between the harm avoidance scores and rs1800497 in AA smokers (1-way ANOVA, p-value=0.039). Conclusion: Additional research is needed to understand the genetic and social determinants contributing to increased smoking behavior in AA smokers.

Learning Areas:
Diversity and culture
Public health biology
Public health or related research
Social and behavioral sciences

Learning Objectives:
1. Analyze the contribution of environmental factors and the BIS harm avoidance personality trait to smoking behaviors in African-Americans. 2. Evaluate the genetic contribution of DRD2 SNP rs1800497 to BIS harm avoidance personality traits and smoking behaviors in African-Americans.

Keywords: African American, Smoking

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: For over 10 years I have worked on several university and foundation sponsored public health and community-building projects. The majority of my research has been conducted in underserved urban and rural communities, examining the social determinants of health impacting minority and immigrant communities. My project is based on health disparities research conducted with faculty and staff at the Howard University Cancer Center with the SOAR-Health Program under the Georgetown-Howard Center for Clinical and Translational Science.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.