274469 How does tobacco-related cancer incidence and survival vary among areas with different smoking prevalence? Analysis of Surveillance Epidemiology and End Result (SEER) nine registries database, 1975-2009

Monday, October 29, 2012

Mohammed Al-Temimi, MBChB MPH , Department of Family and Preventive Medicine, University of Utah, Salt lake City, UT
Yuan-Chin Lee, PhD , Department of Family and Preventive Medicine/Division of Public Health, University of Utah, Salt Lake City, UT
Mia Hashibe, PhD , Department of Family and Preventive Medicine/Division of Public Health, University of Utah, Salt Lake City, UT
Background Tobacco-smoking is an established risk factor of certain cancer types; therefore, variability of smoking prevalence is expected to be associated with variability in the rates of these cancers. Utah has the lowest smoking prevalence in the nation; therefore, our objective is to describe the differences in incidence, survival and temporal trends of tobacco-related cancers between Utah and eight other registries using the Surveillance Epidemiology and End Result (SEER) nine registries database. Methods Invasive primary tobacco-related cancers were identified in the SEER database (1975-2009). SEERstat was used to calculate age-adjusted incidence and five-year relative survival rate. Smoking prevalence was abstracted from the literature and temporal trends were analyzed using JointPoint regression program. Results Between 1975 and 2009, tobacco-related cancer rate dropped by 0.4% per year among men in both areas and increased by 0.5% and 0.2% per year among women in Utah and the other registries respectively. Utah had lower smoking prevalence, higher five year relative survival (43.5% vs. 39.3%) and 40-45% lower rate of tobacco-related cancer than the other areas. In all registries, overall tobacco-related cancer rate declined by 0.9 % per year, however, cancers of the kidney, liver, and pancreas increased among both sexes, while esophageal and oropharyngeal cancers increased only among men. Conclusion Low smoking prevalence is associated with lower rate and better survival of tobacco-related cancer. Overall tobacco-related cancer rate is declining; however, this trend is not consistent for all sub-sites. Further research is necessary to identify why some tobacco-related cancers are increasing.

Learning Areas:

Learning Objectives:
1. Comapre the temporal incidence and survival trends of tobacco-related cancers among areas with different smoking prevelance.

Keywords: Cancer, Tobacco

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I have been the first author of papers published in peer-reviewed journals. Also I successfuly presented my work at national conferences. My interests are cancer prevention, trauma prevention and health care delivery.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.