Association of birth weight with metabolic markers of cardiovascular risk later in life
Objectives: To examine the longitudinal association of BW with several metabolic biomarkers up to mid-adulthood.
Methods: Data were obtained from the Bogalusa Heart study. Participants were 2262 school aged students followed from 1971 to 2001. The study used a longitudinal repeated measures design. Birth weight data were obtained from birth records. The association of BW with: serum triglycerides, total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and insulin resistance (HOMA-IR) was examined. Linear mixed model analysis was used to assess the longitudinal association of BW with change of the outcomes over time. A separate model was constructed for each outcome and adjustment for many behavioral and socio-economic confounders was performed. Log transformation was made for outcomes with non-normal distribution.
Results: Participants were 63.4% White and 36.6% African American. Mean age (at last measurement) 31.7 ± 5.2. Birth weight was inversely associated with total cholesterol (β = -2.45, p = .013), log HOMA-IR (β = -.061, p <.001) and log triglycerides (β = -.036, p = .003). There was no association of BW with HDL (p = .20) or LDL (p = .66).
Conclusion: In this population, persons with lower BW tend to have more adverse metabolic profile at mid-adulthood.
Learning Areas:Chronic disease management and prevention
Assess the association of birth weight with metabolic markers of cardiovascular risk Compare the strength of association of birth weight across the different markers of CV risk
Qualified on the content I am responsible for because: I have been working on this dataset for some time now and am currently working on a manuscript for publication.
Any relevant financial relationships? No
I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.