Role of topical antibiotics to prevent endophthalmitis after intravitreal anti-vascular endothelial growth factor injection
Methods: A retrospective review of intravitreal injections administered at one large retina practice between January 1, 2009 and October 1, 2012 was performed. For the first 32 months of the study period, topical antibiotics were prescribed for 4 to 5 days post-injection. During the remaining 13 months of the study, topical antibiotics were not prescribed. The rates of endophthalmitis between the two time periods were analyzed.
Results: A total of 104,870 injections were administered to 13,568 patients during the study period. Post-injection topical antibiotics were prescribed after 63,147 of the injections. Thirty-one cases of endophthalmitis occurred in this group (incidence rate 0.049%). Antibiotics were not given following 41,723 injections, among which 13 cases of endophthalmitis occurred (incidence rate 0.031%). Incidence of endophthalmitis for patients prescribed topical antibiotics was not significantly different from patients not using antibiotics (p=0.17).
Conclusion: The incidence of endophthalmitis following intravitreal injection is low. Routine use of post-injection antibiotic drops does not appear to significantly reduce the risk of developing endophthalmitis.
Learning Areas:Basic medical science applied in public health
Chronic disease management and prevention
Clinical medicine applied in public health
Other professions or practice related to public health
Provision of health care to the public
Evaluate the role of topical antibiotics in preventing ocular infection for patients receiving injections for the treatment of age-related macular degeneration
Keyword(s): Vision Care, Infectious Diseases
Qualified on the content I am responsible for because: I have worked as a post-baccalaureate student and research assistant on multiple studies evaluating the safety and efficacy of medical and surgical interventions for retinal disease. Among my scientific interests are infectious disease and outcome results from clinical studies applied to the public health sphere.
Any relevant financial relationships? No
I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.