Online Program

Biological and environmental modifiers of vitamin D3 and prostate cancer risk study: A model for disparities research in urban environments

Monday, November 4, 2013

Sara Agate, BA, Institute of Human Genetics, and School of Public Health, University of Illinois at Chicago, Chicago, IL
Rick Kittles, PhD, Institute of Human Genetics, University of Illinois at Chicago, Chicago, IL
Adam Murphy, Dept. of Urology, Northwestern University, Chicago, IL
Jennifer Newsome, MS, Institute of Human Genetics, University of Illinois at Chicago, Chicago, IL
Maria Ruden, MS, Institute of Human Genetics, University of Illinois at Chicago, Chicago, IL
Prostate cancer (Pca) disparities are caused by interactions of genetics, individual risk factors, and environmental factors. Recent studies report low levels of vitamin D are associated with increased Pca risk. This is a multicenter study of genetic and environmental factors, which influence vitamin D3 levels and Pca risk in African Americans (AAs), European Americans (EAs), and Hispanic Americans (HAs). The project goal is to explore the effects of serum Vitamin D, and its biological and environmental modifiers on Pca risk in 4,000 males from Chicago. Males aged 40-79 are being recruited from urology clinics at a consortium of Chicago public and private hospitals including, the University Illinois Hospital & Health Sciences System, Northwestern Memorial Hospital, John H. Stroger, Jr. Hospital of Cook County, University of Chicago Medical Center, and the Jesse Brown Veteran Affairs Medical Center. They are also recruited at community Pca screening events. To date we have recruited 1,179 males. A significant number of the AA (46.2%), and HA (78.9%) males were recruited from the public hospitals, whereas, almost all EA males (91.3%) were recruited mainly from the private, academic hospital. Clinical and socioeconomic factors also vary considerably across sites and ethnicity. Recruitment strategies include physician referrals at the biopsy clinic, community cancer screenings, visits to churches, and culturally competent clinical research coordinators. This large-scale study of vitamin D3 and Pca risk in disparate populations can serve as a model for strategies in the recruitment of diverse populations in urban environments.

Learning Areas:

Diversity and culture

Learning Objectives:
Identify the challenges of minority recruitment in urban hospitals. Differentiate between the academic public, and private hospitals in Chicago, Illinois. Assess the value of culturally competent clinical research coordinators in the recruitment of minorities.

Keyword(s): Cancer, Minority Research

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I have been a clinical research coordinator for this study since January 2012. As part of my role, I have been primarily responsible for the recruitment of patients at the University of Illinois Hospital and Health Sciences System, as well as John H. Stroger, Jr. Hospital of Cook County.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.