Online Program

284012
Time to definitive diagnosis of breast cancer in Latina and non-Hispanic white women: The six cities study


Sunday, November 3, 2013

Amelie Ramirez, DrPH, Dept of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, TX
Eliseo J. Perez-Stable, M.D., Department Medicine, University of California, San Francisco, San Francisco, CA
Gregory Talavera, MD, MPH, Graduate School of Public Health, San Diego State University, San Diego, CA
Frank Penedo, PhD, Department of Medical Social Sciences / Northwestern University, Northwestern University, Chicago, IL
J. Emilio Carrillo, MD, MPH, Weill Cornell Medical College, Cornell University, New York, NY
Maria E. Fernandez, PhD, Health Promotion and Behavioral Sciences, University of Texas Health Science Center at Houston, School of Public Health, Houston, TX
Edgar Munoz, MS, The Institute of Health Promotion Research, Dept of Epidemiology and Biostatistics, The University of Texas Health Science Center at San Antonio, San Antonio, TX
Dorothy Long Parma, MD, MPH, Institute for Health Promotion Research, University of Texas Health Science Center at San Antonio, San Antonio, TX
Alan Holden, PhD, The Institute for Health Promotion Research, Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, TX
Sandra San Miguel, MS, Department of Epidemiology & Biostatistics, Institute for Health Promotion Research, The University of Texas Health Science Center at San Antonio, San Antonio, TX
Anna Napoles, Ph.D., Center for Aging in Diverse Communities, University of California, San Francisco, CA
Sheila Castaneda, PhD, Graduate School of Public Health, San Diego State University, San Diego, CA
Kipling Gallion, MA, Dept of Epidemiology and Biostatistics, UT Health Science Center at San Antonio, San Antonio, TX
Delays between an abnormal screening mammogram and definitive diagnosis of breast cancer may critically impact tumor size, stage at diagnosis, treatment, prognosis, and survival. This study was undertaken to evaluate disparities between Latina and non-Hispanic white (NHW) women in time to definitive diagnosis of breast cancer after an abnormal screening mammogram, as well as contributing factors. Clinical records of 186 Latinas and 74 NHWs with abnormal screening mammograms were reviewed to determine time to definitive diagnosis. Data was obtained from participating clinics in six U.S. cities and included demographics, clinical history, and mammogram characteristics. Kaplan-Meier estimates and Cox proportional hazards models were used to test differences in median time to definitive diagnosis (MTTD) by ethnicity, adjusting for clinic site, demographics, and clinical characteristics. Time-to-event analysis showed Latinas taking 2.2 times longer to reach 50% definitively diagnosed with breast cancer vs. NHWs, and three times longer to reach 80% diagnosed (p=0.001). Latinas' MTTD was 60 days vs. 27 for NHWs, a 59% gap in diagnosis rates (adjusted Hazard Ratio [aHR]=1.59, 95% CI=1.09, 2.31; p=0.015). BI-RADS-4/5 women's diagnosis rate was more than twice that of BI-RADS-3 (aHR=2.11, 95% CI=1.18, 3.78; p=0.011). Disparities in time between receipt of abnormal screening result and definitive diagnosis adversely affect Latinas compared to NHWs, and remain significant after adjusting for demographic and clinical variables. With cancer now the leading cause of mortality among Latinos, a greater need exists for ethnically- and culturally-appropriate interventions to facilitate Latinas' successful entry into, and progression through, the cancer care system.

Learning Areas:

Clinical medicine applied in public health
Diversity and culture
Public health or related research
Social and behavioral sciences

Learning Objectives:
Compare time to definitive diagnosis of breast cancer in a 6-city sample of Latina vs. non-Hispanic white women Discuss factors contributing to definitive diagnosis delay

Keyword(s): Health Disparities, Health Care Delivery

Presenting author's disclosure statement:

Not Answered