Relationships between diabetes medication and the risk of acute myocardial infarction, stroke, and coronary artery heart disease in patients with type 2 diabetes -participants in Taiwan national diabetes care management program
Methods This study planned a retrospective cohort study consisting of 57,545 Chinese patients with type 2 diabetes who were enrolled in the Taiwan National Diabetes Care Management Program. The baseline period was at 2001−2003 and all identified patients were followed up until December 2010. Extensive adjustments for demographic and clinical variables were made by using Cox proportional hazards regression.
Results A total of 26,840 end points were observed during a median follow−up of 7.3 years. The adjusted hazard ratios of the composite of acute myocardial infarction, stroke, or coronary artery heart disease for patients having three oral medications, insulin only, insulin plus one oral medication, and insulin plus more than one oral medications compared with patients who did not have medication were 1.10 (95% confidence interval: 1.03,1.17), 1.31 (1.19,1.44), 1.27 (1.13,1.42), and 1.35 (1.23,1.49), respectively.
Conclusions Our findings indicated that patients with three oral medications, insulin used, either combined with oral medication or not, had an increased risk of acute myocardial infarction, stroke, or coronary artery heart disease.
Learning Areas:Biostatistics, economics
Chronic disease management and prevention
Clinical medicine applied in public health
Public health or related research
Compare diabetes medication with the risk of acute myocardial infarction, stroke, and coronary artery heart disease in patients with type 2 diabetes.
Keyword(s): Diabetes, Drug Use
Qualified on the content I am responsible for because: I am a graduate institute of biostatistics student.
Any relevant financial relationships? No
I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.