Mortality among people with hepatitis c and HCV/HIV co-infection in New York city, 2000-2011
Methods: The NYC Department of Health and Mental Hygiene (DOHMH) implemented CDC's Program Collaboration and Service Integration initiative to better understand the interaction between infectious diseases in NYC. We conducted a retrospective, deterministic cross-match of HIV and HCV surveillance databases with data from 2000-2010, and NYC death registry data from 2000-2011. We examined changes in the proportion of HCV cases with HIV over time, and used survival analysis to compare progression to death in the two groups over the 10-year period, controlling for age.
Results: Of persons diagnosed with HCV in 2000, 8% were diagnosed with HIV. This proportion of co-infected HCV cases increased to 17% in 2010. During the study period, 19% of HCV/HIV co-infected persons died within 3 years of their HCV diagnosis, compared with 9% of persons with HCV only (<.0001). The annual risk of death was 5.5 times higher for co-infected cases compared with the HCV-only group (p<.0001).
Conclusion: Given the higher risk of death among persons with HCV/HIV co-infection, the NYC DOHMH is developing a strategy to improve HCV testing among people with HIV, and to prioritize linkage to medical care for co-infected persons who are not in care.
Learning Areas:Chronic disease management and prevention
Public health or related research
Describe how surveillance and vital records data can be used for population level analysis of HCV/HIV co-infection
Keyword(s): Hepatitis C, Surveillance