Online Program

Vitamin d and inflammation status in postmenopausal American Indian women

Tuesday, November 5, 2013 : 2:54 p.m. - 3:06 p.m.

Irina V. Haller, PhD, MS, Division of Research, Essentia Institute of Rural Health, Duluth, MN
Ellen Fidler, BS, UW Osteoporosis Clinical Research Program, University of Wisconsin - Madison, Madison, WI
Kate Cronin, MPH, Department of Family Medicine, University of Wisconsin, Madison, WI
Debra Roth, RN, Stockbridge-Munsee Health and Wellness Center, Bowler, WI
Diane Krueger, BS, UW Osteoporosis Clinical Research Program, University of Wisconsin - Madison, Madison, WI
Alexandra Adams, MD, PhD, Collaborative Center for Health Equity, Institute for Clinical and Translational Research UW School of Medicine & Public Health, University of Wisconsin - Madison, Madison, WI
Neil Binkley, MD, UW Osteoporosis Clinical Research Program, University of Wisconsin - Madison, Madison, WI
Low vitamin D (D) status is common worldwide; it adversely affects bone health and may have multiple detrimental consequences including increased rates of chronic disease potentially mediated via effects on systemic inflammation. The relationship between vitamin D and inflammation status in American Indian (AI) populations has received very limited study. This is the first randomized controlled trial to test the effect of D supplementation on systemic markers of inflammation in AI women. Community-dwelling postmenopausal women (n=99) were recruited at a tribal clinic in northern Wisconsin for the 6 month trial. At baseline, women were 60.8±7.3 (±SD) years old with BMI of 33.1±7.0 kg/m2; 46% reported using multivitamin or D supplements. D levels were low: screening mean serum 25-hydroxyvitamin D [25(OH)D] was 24.8±11.3 ng/mL; 7% of women had 25(OH)D ≤10 ng/mL, 33% (10.1 to 19.9 ng/ml), 30% (20 to 29.9 ng/ml), and 31% (≥30 ng/mL). The prevalence of D insufficiency (<20 ng/ml) was 39% and similar to our earlier data for AI women from Minnesota. Compared to NHANES data, prevalence of low D for AI women is between that for white (20%) and Mexican American women (48%). The 25(OH)D levels were unrelated to BMI. Baseline c-reactive protein (CRP) was high 4.6±4.9 mg/L and was positively correlated (p<0.01) with 25(OH)D. In conclusion, D inadequacy is common in AI women, is associated with elevated CRP but not BMI. Work is ongoing to determine the effect of D supplementation on inflammation, and will assist AI communities in developing further interventions to reduce chronic disease.

Learning Areas:

Chronic disease management and prevention
Clinical medicine applied in public health

Learning Objectives:
Describe vitamin D status in postmenopausal American Indian women Discuss relationship between vitamin D status and inflammation, as measured by c-reactive protein (CRP) Compare inflammation status of American Indian women to other populations

Keyword(s): American Indians, Women's Health

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I have been the principal investigator or co-investigator on a number of grants related to vitamin D status and it's relation to chronic diseases in rural and American Indian populations. Among my scientific interests have been the development of strategies for improving vitamin D status.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.