Early onset of menarche associated with internal carotid artery intima-media thickness in asymptomatic black-white younger adult women: The bogalusa heart study
Methods: This aspect was examined in a cohort of 575 black and white women (31% black, 69 % white) aged 24-43 years (mean 35.9 years) enrolled in the Bogalusa Heart Study. B-mode ultrasound images of the far walls of both carotid arteries were obtained. The early onset of menarche defined as less than 12 years of menarche age.
Results: Black women vs. white women had significantly later onset of menarche age (12.91 and 12.51 mean year, p=0.007). Internal carotid artery IMT was higher in black women vs. white women (0.688 vs. 0.671 μm, p =0.04). In a stepwise multivariate regression model, adjusting for race, age, waist circumference, homeostasis model assessment of insulin resistance (HOMA-IR) and triglycerides/ HDL cholesterol ratio, early onset of menarche remained independently and adversely associated with internal carotid IMT (p=0.03).
Conclusions: The observed deleterious effect of early onset of menarche on carotid IMT in asymptomatic black-white younger adult women underscores the importance of public health implications.
Learning Areas:Chronic disease management and prevention
Public health or related education
Describe the public health importance of early onset of menarche
Keyword(s): Chronic (CVD), Reproductive Health
Qualified on the content I am responsible for because: I am a faculty member in Jackson State University, Mississippi.
Any relevant financial relationships? No
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