Variation in the sodium-dependent vitamin c transporter 2 gene is associated with risk of acute coronary syndrome among women
Background: The sodium-dependent vitamin C transporter 2 (SVCT2) is responsible for the transport of vitamin C into cells, and malfunction of this protein leads to reduced vitamin C uptake in the arterial wall. We tested the hypothesis that candidate variations rs6139591 and rs1776964 in the SVCT2 coding gene (SLC23A2) are associated with development of acute coronary syndrome. Design: In the Danish Diet, Cancer and Health cohort study, we performed a case-cohort study among subjects aged 50-64 years. Results: During a mean follow-up period of 6.4 years, we identified 936 cases and randomly selected a sub-cohort (n=1,580) with full information on genotypes and covariates. Using Cox proportional hazard models, we found that rs6139591 TT women with an estimated dietary vitamin C intake below the median had a higher risk of acute coronary syndrome compared with female CC homozygotes (adjusted HR 5.39, 95% CI, 2.01-14.50). For rs1776964, we again found a higher risk (adjusted HR 3.45, 95% CI, 1.1610.28) among TT-homozygous women with above-median vitamin C intakes, as compared with the CC genotype and low vitamin C intake. Among men, weaker and non-significant associations were observed for both polymorphisms. Conclusion: Genetic variation in the sodium-dependent vitamin C transporter-2 is associated with risk of incident acute coronary syndrome in women. The genotype effects may be partially compensated by a higher dietary intake of vitamin C. Sufficient vitamin C intake is therefore particularly important in genetic SVCT subgroups.
Describe susceptibility to acute coronary syndrome caused by genetic variation in the sodium-dependent vitamin C transporter 2 gene
Keyword(s): Genetics, Myocardial Infarction
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Qualified on the content I am responsible for because: I have been the principal or co-principal of national and international funded grants focusing on the gene-diet interaction and the effects on obesity, insulin resistance and cardiovascular disease risk. Among my scientific interests are to determine contribution of âintermediate riskâ susceptibility genes in cardiovascular disease, obesity and type 2 diabetes and their interaction with diet and environmental factors
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