Short-term psychological benefits to consumer genetic testing: Findings from the pgen study
Results: Two weeks post-disclosure, customers showed minor decreases in general anxiety (Δ=-.22, p<.001) and depression (Δ=-.14, p<.001), while showing increases in positive affect (Δ=.15, p=.002). However, differences from baseline were no longer statistically significant 6 months after disclosure (GAD: Δ=-.07, p=.10; PHQ: Δ=-.04, p=.31; MHI: Δ=-.06, p=.24). Results-specific distress decreased between the 2 week and 6 month follow-ups ( Δ=-.43, p=.005) as did results-specific positive affect (Δ=-.37, p<.001).
Conclusions: Consumers' moods improved immediately after disclosure of genetic profiles and returned to baseline over time. Results are consistent with prior findings from research on consumer genetic testing. Ongoing analyses in the PGen Study will examine how specific genetic profile results affected emotional responses.
Learning Areas:Conduct evaluation related to programs, research, and other areas of practice
Provision of health care to the public
Social and behavioral sciences
Describe psychological responses to consumer genetic testing and how they change over time.
Keyword(s): Genetics, Depression
Qualified on the content I am responsible for because: I work on numerous NIH-funded studies examining the psychological impact of genetic susceptibility information, and am PI of an NHGRI grant exploring the psychosocial impact of incidental genetic information disclosure. My PhD dissertation focused on psychological responses to APOE genotyping for Alzheimer's disease risk, and my training focused on health behavior/health education with certification in public health genomics.
Any relevant financial relationships? No
I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.