Online Program

Association of dyslipidemia and prostate cancer in African American men

Monday, November 4, 2013 : 11:16 a.m. - 11:32 a.m.

Sparkle Springfield, BS, Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL
Adam Murphy, Dept. of Urology, Northwestern University, Chicago, IL
Iman K. Martin, MPH MS PhD, Division of Epidemiology and Biostatistics, University of Illinois at Chicago School of Public Health, Chicago, IL
Chiledum Ahaghotu, MD, Department of Urology, Howard University Hospital, Washington DC, DC
Rick Kittles, PhD, Institute of Human Genetics, University of Illinois at Chicago, Chicago, IL
Background: Dyslipidemia is linked to prostate cancer (PCa) risk but has not been evaluated in African Americans (AAs). We evaluated the association of dyslipidemia [elevated total cholesterol, triglycerides, and/or low density lipoproteins (LDL)] and odds of PCa. Methods: From 2000 – 2004, 250 AA men, age 40-79 years were recruited from an urban academic urology clinic. In this case-control study, there were 141 incident PCa cases and 109 healthy controls. Results: Median age was 60.0y/o in controls and 69.0y/o for cases (p < 0.001). Median Prostate Specific Antigen (PSA) is 2.0ng/ml in controls vs. 7.4ng/ml in cases (p = 0.04). PCa family history was reported in 14.9% of controls and 19.2% of cases (p = 0.41). Overall, 31.2% of controls were obese versus 25.5% of cases (p = 0.37). Median total cholesterol was 195.3mg/dL in controls and 191.1mg/dL in cases (p = 0.42). There were similar rates of elevated LDL and total cholesterol (both p > 0.30), while elevated triglycerides occurred in 16.5% of controls and 25.5% of cases (p = 0.09). Dyslipidemia was diagnosed in 23.3% of controls and 35.5% of cases (p = 0.028). On binary logistic regression for PCa status, there was a significant interaction between obesity and dyslipidemia (OR 6.21, p = 0.04) after adjusting for age, PSA, PCa family history and smoking. There were no associations found between serum lipids and tumor grade (i.e. Gleason > 6 or > 7). Conclusions: Dyslipidemia significantly interacts with obesity and is associated with increased odds of PCa.

Learning Areas:

Public health biology

Learning Objectives:
List the subtypes of dyslipidemia that are associated with increased prostate cancer odds.

Keyword(s): African American, Cancer

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am a PHD candidate at University of Illinois is the Department of Kinesiology and Nutrition. I focus on obesity, metabolic syndrome, nutrition and cancer prevention. I am co-mentored by Dr. Rick Kittles PhD. The co-authors and I performed the relevant statistical analyses to develop this abstract and I have already presented on related topics at other national research conferences.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.