Online Program

Association between intestinal infections and development of irritable bowel syndrome (IBS)

Sunday, November 3, 2013

G. Reza Najem, MD, MPH, PhD, Preventive Medicine and Community Health, New Jersey Medical School, Newark, NJ
Deborah Ablordeppey, MPH, Dept Preventive Medicine and Community Health, C/A UMDNJ-New Jersey Medical School, Newark, NJ
METHODS: Systematic review of the medical literature (1999-2012) was used to find 7 case-control studies of association between intestinal infections and development of Irritable Bowel Syndrome (IBS). Meta-analysis was used to evaluate the association. 95% CI (confidence interval) was calculated for exposed and non-exposed controls. Test of heterogeneity was also performed. RESULTS: The median incidence of IBS in the cases was 8% (Range 4.0–31) and for the controls 1% (0.3 - 11). However, the lower limits of 95% CI for 3 studies were lower than 1 odd ratio (OR). One study had a wider CI is considered to be caused by small sample size. The other 4 studies show significantly greater-than-1 OR. Specifically, two have narrower CIs due to the relatively large sample sizes. For the pooled studies, the OR based on The Mantel-Haenstzel fixed effects model was 4.1 (95% CI 3.3–5.1). A random effects model was used, as the test shows with significant heterogeneity (p < 0.0001). CONCLUSIONS: This study is consistent with previous research; we found that the individuals who have Intestinal Infections are more likely to develop IBS

Learning Areas:


Learning Objectives:
Evaluate the association of Irritable Bowel Syndrome with Intestinal Infection.

Keyword(s): Infectious Diseases, Risk Assessment

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I designed the study
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.