Effect of coffee consumption on all-cause and cardiovascular disease mortality
Objective: To evaluate the association between coffee consumption and mortality from all causes and cardiovascular disease (CVD). Methods: Data were from the Aerobics Center Longitudinal Study (ACLS) cohort. A total of 43,727 participants, contributing to 16,062 person-years of follow-up time, were included in final analysis. Data were collected by an in-person interview based on standardized questionnaires and a medical examination including fasting blood chemistry analysis, anthropometry, blood pressure, electrocardiography, and a maximal graded exercise test. Cox regression analysis was used to quantify the association between coffee consumption and all-cause and cause-specific mortality. Results: During the 17-year median follow-up period, 2512 deaths occurred (men: 87.5%; women: 12.5%) and 32% were due to CVD. In multivariate analysis, coffee intake was positively associated with all-cause mortality in men, but not in women. Men who drank >28 cups of coffee per week had higher all-cause mortality (hazard ratio: 1.21; 95% CI: 1.04-1.40). However, after stratification based on age, both younger (<55 years) men and women showed a statistically significant association between high coffee consumption (>28 cups/week) and all-cause mortality after adjusting for the potential confounders and fitness level (hazard ratio: 1.56; 95% CI: 1.30-1.87 for men and hazard ratio: 2.13; 95% CI: 1.26-3.59 for women, respectively). Conclusion: In this large cohort the positive association between coffee consumption and all-cause mortality was observed among men and both men and women <55 years of age. Hence, it may be appropriate to recommend that younger people should avoid heavy coffee consumption (> 4 cups on typical days).
Advocacy for health and health education
Provision of health care to the public
Public health or related education
Public health or related public policy
Public health or related research
Define how much coffee is dangerous for different age groups
Explain the risks of drinking large quantities of coffee
Describe health conditions that may magnify the risks of coffee
Keyword(s): Mortality, Chronic (CVD)
Presenting author's disclosure statement:
Qualified on the content I am responsible for because: I am a Ph.D candidate of Epidemiology, and I am responsible for hypothesis generating, data analysis and interpretation, and manuscript writing of the current work under the guidance of my supervisor.
Any relevant financial relationships? No
I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines,
and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed
in my presentation.