Online Program

Time Space Continuum of Measles Diagnosis

Monday, November 4, 2013 : 11:00 a.m. - 11:10 a.m.

Catherine Moore, Welsh Specialist Virology Centre, Public Health Wales, Cardiff, UK CF14 4XW, Wales
This presentation will describe the challenges involved in the development and rapid implementation of a home-brew real-time PCR for measles to support the management of an outbreak in South Wales and the pressures involved in meeting the diagnostic requirements of a nation.

This is the first large outbreak of measles in the UK that has been actively managed using this diagnostic tool. The utility of various sample types will be described including the use of patient self-collected dry mouth swabs as a novel sampling tool. The presentation will explore the elements of data interpretation comparing classical serological assays with a molecular assay in a previously and recently vaccinated population. It will describe the different laboratory observations in the various sub populations within the outbreak, such as early infection, late infection and vaccinated individuals. It will review the various interpretive conclusions of the assay results in the context of the clinical presentation, patient symptoms, onset dates and duration of viral shedding. The audience will be informed of the overall benefit of this molecular service and its place in the resolution of the measles outbreak.

Learning Areas:

Protection of the public in relation to communicable diseases including prevention or control

Learning Objectives:
Evaluate the benefit of rapid diagnosis, the novel sampling techniques and the clinical interpretation of this investigative tool.

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am the Principal Clinical Scientist in Wales for the development and implementation of molecular diagnostic assays for the detection and diagnosis of viral infection including novel viral pathogens. My primary expertise is in the diagnosis and understanding of respiratory virus infection. The development of the all Wales molecular diagnostic service for respiratory viruses became the basis of my PhD by published work and I have presented extensively at national and international scientific meetings.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.