141st APHA Annual Meeting

In This section

283290
Examination of factors associated with cancer survival among complex patients using competing risk model

Tuesday, November 5, 2013

Fei Tan, PhD , Mathematical Sciences, Indiana University-Purdue University Indianapolis, Indianapolis, IN
Hong Xiao, PhD , Econominc, Social & Administrative Pharmacy, Florida A&M University, Tallahassee, FL
Lenonidas Koniaris, MD , Thomas Jefferson University Hospital, Philadelphia, PA
Georges Adunlin, MA , Econominc, Social & Administrative Pharmacy, Florida A&M University, Tallahassee, FL
Askal Ali, MA , Econominc, Social & Administrative Pharmacy, Florida A&M University, Tallahassee, FL
Sriharsha Gummadi, BS , Department of Surgery, Jefferson Medical College, Philadelphia, PA
Jason Feldman, MPH , Bureau of Epidemiology, Florida Department of Health, Tallahassee, FL
Youjie Huang, MD, DrPH , Bureau of Epidemiology, Florida Department of Health, Tallahassee, FL
Background: Approaches to describe risk of disease include Cox proportional hazards regression; however, this method fails to account for the competing risk of death. Purpose: To determine significant predictors of breast cancer-specific-survival among female breast cancer (BCa) patients while allowing competing risk for other causes of death. Methods: 4220 BCa patients identified from Florida cancer registry between 2007 and 2010 were linked with their electronic medical records. Competing risk survival model was used for analysis. Results: Two-year cumulative BCa death and death from other causes were 4.83 and 2.89 percent respectively. Median follow-up for patients who died from BCa and from other causes were 569 and 642 days respectively. Multivariate competing risk model showed that increased chance of BCa death was associated with black race, triple negative status with effect increased over time, unknown biomarker receptor status, being unmarried, Medicare reliance, having poorly- or un-differentiated tumor grade, regional diagnosis stage, larger tumor size, and more positive nodes detected. Higher probability of death from other causes was associated with being diagnosed at an older age, being unmarried, Medicaid recipients or Medicare beneficiaries, having more comorbidity, moderately-differentiated tumor grade, poorly- or un-differentiated tumor grade, larger tumor size, not having chemotherapy, and having less lymph nodes examined. Temporal increase of detrimental triple negative effect on BCa survival appeared in competing risk model but was not observed in Cox model. Conclusions: Competing risk model may be a better tool in examining factors associated with cancer survival among patients with complex conditions.

Learning Areas:
Biostatistics, economics
Public health or related organizational policy, standards, or other guidelines

Learning Objectives:
Demonstrate use of competing risk model Compare factors identified by traditional cox model and competing risk model

Keywords: Women's Health, Cancer

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am a co-investigator for the Expansion Research Capability to Study Comparative Effectiveness in Complex Patients project
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.