Association between family history of high cholesterol and childhood obesity using a longitudinal study of fifth grade Appalachian children
Methods: The study used longitudinally linked data from two cross-sectional datasets (the WV Birth-Score Project and the CARDIAC project) in West Virginian children (N=22,136). The main outcome variable was fifth-grade BMI percent above ideal (BMI%) and the main exposure was defined as parent reported family history of cholesterol. Covariates included sex, race, maternal and paternal education, child’s birth-weight, maternal smoking during pregnancy, breastfeeding intent, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C).
Results: The mean BMI% of children who had a family history of cholesterol was significantly higher compared to children who had no family history of cholesterol: 21.68% (95%CI: 21.10 – 22.27) versus 18.36% (95%CI: 17.94 – 18.78; p<0.0001). Multiple regression analysis showed that family history was significantly and positively associated with BMI% after controlling for covariates (p<0.0001, Adj. R-square = 0.1831).
Conclusion: Our results show a significant but small positive association between family history of cholesterol and childhood obesity after controlling for the child’s cholesterol, gender, race, parental education and smoking, and intent to breastfeed. Our study results suggest that future research should focus on more proximal factors that contribute larger amounts of variance in the child’s BMI%, compared to role of genetics or family history of cholesterol, which may be a more distal factor.
Learning Areas:Chronic disease management and prevention
Discuss the role between family history of high cholesterol and childhood obesity
Keyword(s): Obesity, Chronic Disease Prevention
Qualified on the content I am responsible for because: I am currently doing PhD in Epidemiology. I am interested in conducting research on various aspects of childhood obesity and the role of various factors associated with childhood obesity and cardiovascular disease.
Any relevant financial relationships? No
I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.