Online Program

Changes in Inflammation Associated with Fish Oil Supplementation

Tuesday, November 3, 2015 : 8:30 a.m. - 8:45 a.m.

Rodney G. Bowden, PhD, Robbins College of Health and Human Sciences, Baylor University, Waco, TX
Erika Deike, PhD, Baylor University
Jen Moreillon, PhD, Baylor University
Jackson Griggs, MD, Family Health Center
Brian Shelmadine, MD. PhD, Baylor University
A. Alexander Beaujean, PhD, PhD, Department of Educational Psychology, Baylor University, Waco, TX
Objective: A characteristic of chronic kidney disease (CKD) is excessive production of pro-inflammatory cytokines.  The benefits of fish oil (FO) for an extensive range of populations and health concerns are apparent, yet the anti-inflammatory benefits for non-dialysis CKD patients are equivocal. Therefore, the purpose of this study was to investigate the effects of daily consumption of FO on IL-1β, IL-6, and TNF-α for 8 weeks in non-dialysis CKD patients.  Design, Setting, and Subjects: The study was conducted using a double blind, randomized, placebo-controlled experimental design.  Thirty-one non-dialysis CKD patients were followed prospectively for 8 weeks while supplementing FO (2.4g/day (1400 mg EPA + 1000 mg DHA) or placebo (safflower oil) in their diet.  Main Outcome Measures: IL-1β, IL-6, and TNF-α were all measured as markers of inflammation at pretest and at 8-weeks.  Results: One-way ANOVA revealed no significant differences in IL-6 (p=.06), IL-1β (p=.18), and TNF-α (p=.20) between groups at baseline.  Additionally, no pretest differences existed between groups for age (p=.549), weight (p=.324), waist circumference (p=.086), gender (p=.591) and ethnicity (p=.875).   ANCOVA was calculated using compliance, age, gender, ethnicity, body weight, and waist circumference as covariates. No significant differences were discovered between groups after FO supplementation for IL-6 (p=.453), and TNF-α (p=.242).  A significant difference was discovered for IL-1β (p=.050) with lower levels in the FO group.  Conclusions:  The results of this study is in agreement with some previous studies that suggest that FO supplementation has no effect on plasma pro-inflammatory cytokines TNF-α or IL-6, but does have an effect on IL-1β in non-dialysis CKD patients.  The protective effects in this study and others are due primarily to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found in FO.  Inflammation plays a significant role in cardiovascular disease in CKD patients with novel approaches needed to reduce the risk of cardiovascular disease.

Learning Areas:

Chronic disease management and prevention

Learning Objectives:
Assess the effects of fish oil on inflammatory markers Explain inflammatory cytokines Compare changes in inflammatory cytokines between a fish oil and control group

Keyword(s): Chronic Disease Management and Care, Nutrition

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am the PI for this study
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.