Online Program

Genetic variants in the PDLIM5 gene are associated with alcohol dependence and cancer

Monday, November 2, 2015 : 8:50 a.m. - 9:10 a.m.

Daniel Owusu, DrPH, Department of Biostatistics and Epidemiology, East Tennessee State University, Johnson City, TN
Yue Pan, PhDc, Miller School of Medicine, University of Miami, Miami, FL
Xie Changchun, , PhD, Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA., Cincinnati, OH
Ke-Sheng Wang, PhD, Department of Biostatistics and Epidemiology, East Tennessee State University, Johnson City, TN
Background: Alcohol consumption is one of the most important known risk factors for the development of several types of cancer, however it is increasing worldwide. PDLIM5 gene may play a role in cancer, bipolar, and schizophrenia; however, few studies have focused on the association of PDLIM5 with alcohol dependence (AD). The purpose of this study is to test the associations of PDLIM5 gene polymorphisms with AD and cancer.

Methods:This study examined 72 SNPs in the SAGE sample with 1,066 AD cases and 1,278 controls and 47 SNPs in the Marshfield sample with 1,442 cancer cases (any diagnosed cancer omitting minor skin cancer) and 2,112 non-cancer controls. Logistic regression analysis was performed using PLINK software, adjusted for age and sex.

Results: 16 SNPs were associated with the AD (P<0.01) where rs1048627 showed the strongest signal (P = 5.53 x 10-4). Interesting, 3 of the 16 SNPs also showed associations with cancer (rs6532496, rs7690296, and rs951613 with P = 0.00102, 0.00198, and 0.00138 for AD and P = 0.0214, 0.0475, and 0.0363 for cancer, respectively). Furthermore, the A-C haplotype from rs11732687 and rs11724023 and the T-A haplotype from rs11724023 and rs7690296 revealed significant associations with AD (P = 5.65 x 10-4 and 6.76 x 10-4, respectively).

Conclusion: The present study provides evidence of several genetic variants within PDLIM5 gene influencing the AD and cancer and will serve as a resource for replication in other populations.

Learning Areas:

Biostatistics, economics
Chronic disease management and prevention
Public health or related research

Learning Objectives:
Discuss the association between genetic variants in the PDLIM5 gene and alcohol dependance (AD) List at least 3 alleles within the PDLIM5 gene associated with AD and cancer. Discuss implications of finding for future research.

Keyword(s): Alcohol Use, Genetics

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am a co-author of the research paper, and I have fully participated in the study. I am a first author and I have approval of other authors to present. I have previously co-authored three published papers in genetics. I have also presented in several scientific conferences. As a DrPH (Epidemiology) student, I have adequate knowledge in the field of public health which qualifies me to present.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.