Online Program

A Systematic Review of Naltrexone for women with Alcohol Use Disorders

Tuesday, November 3, 2015

Shantrel Canidate, BS, MPH, Department of Behavioral Science and Community Health, University of Florida, Gainesville, FL
Christa Cook, PhD, MSN, RN, College of Nursing, University of Florida, Gainesville, FL
Robert L. Cook, MD, MPH, College of Public Health and Health Professions, Department of Epidemiology, University of Florida, Gainesville, FL
Giselle Carnaby, PhD, Behavioral Science & Community Health, University of Florida, Gainesville, FL
Approximately 20% of U.S. women have hazardous alcohol consumption levels. Research has shown prescription Naltrexone to be effective in reducing drinking and some studies suggest gender differences in effectiveness. This research seeks to evaluate existing evidence regarding the use of Naltrexone in reducing hazardous drinking among women. A systematic review of clinical trials was conducted (2004 - 2014) using an extensive database search. Search terms, identified a priori included: Naltrexone, alcohol and women. Primary reported drinking outcomes were percent days abstinent, percent drinking days, percent heavy drinking day, and time to first heavy drinking day. Independent raters (n=3) rated study quality using the Downs and Black scale (DBS). For further evaluation, we chose nine studies from 2,631 clinical trials: seven double blind, a single blind, and one factorial design RCT . From the final studies, sample sizes ranged from 100 to 1,383 participants and women accounted for 41% of the total sample. Naltrexone was shown (n=3) to increase percent days abstinent, (n=2) decrease percent drinking days, and (n=2) reduce the risk of heavy drinking in women. DBS evaluation revealed methodological weakness scores across all papers. Final DBS scores ranged from 7.6-26 (M: 18.7, SD: 5.19) and (n=5) ranked above 20 (70% quality cut point) on evaluation. Although, study procedures and measures were diverse, data extracted supports the efficacy of Naltrexone in women. Completion of a future meta-analytic review may provide more information regarding the overall efficacy of naltrexone in women to inform future interventions and policy.

Learning Areas:

Administer health education strategies, interventions and programs
Chronic disease management and prevention
Public health or related public policy
Public health or related research

Learning Objectives:
Discuss the role pharmacotherapies in reducing hazardous drinking Evaluate the effectiveness of pharmacotherapies in the treatment of Alcohol Use Disorders (AUDs) in women

Keyword(s): Alcohol Use, Treatment Efficacy

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am a doctoral student in the Department of Behavioral Science and Community Health at the University of Florida. My scientific interests pertains to HIV/AIDS and my research focuses on reducing hazardous drinking among HIV infected women. I am a 500/501 trained HIV Testing Counselor and the recipient of a diversity supplement from the NIAAA.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.