Joint effects of lipid abnormalities and infection burden on CRP among childbearing age Mexican American women
Purpose: (1) To examine the association of IB with CRP; (2) To investigate interactive effects of IB with TC and HDL on CRP.
Methods: Non-pregnant MA women participants (age 18-49) in the National Health and Nutrition Examination Survey, 1999-2010 (N=1,428). IB summates seropositive status for 3 viruses: Herpes Simplex virus-1 and -2 and Hepatitis B (range 0-3). Categorized as “high” when positive for 2-3 viruses, “low” positive for one virus, and “seronegative”. Lipid categories: TC - low (<160 mg/dL), normal (160-199 mg/dL), borderline high (200-239mg/dL) and high (240 mg/dL and above); HDL - normal (50 mg/dL or greater) and low (< 50 md/dL). CRP dichotomized as normal < 3.0 mg/L and elevated 3.0-10.0 mg/L. Associations were examined using binary logistic regression.
Results: The association between IB and CRP varied based on TC and HDL levels, after adjustment for age, education , waist circumference, diabetes status, and birth control pill use (both P for interaction =0.01). Seropositive women with high TC were 5.42 (95% CI 1.14-25.71) and seropositive women with borderline high TC were 2.82 (95% CI 1.07-7.44) times as likely to have elevated CRP, compared to seronegative women with high and borderline high TC levels, respectively. Women with normal HDL levels had significantly decreased odds of elevated CRP if they were seronegative (OR=0.50, 95% CI 0.26-0.96) or had low IB (OR=0.71, 95% CI 0.54-0.93), compared to women with low HDL level and similar IB status. In women with high IB, anti-inflammatory effect of HDL disappeared (OR=1.32, 95% CI 0.61-2.84).
Conclusion: Lipid abnormalities significantly interact with IB to create heightened inflammation risk. Increased attention to IB/lipid screening and lipid therapy may be needed among CAMAW.
Describe how infection burden and lipid abnormalities jointly create increased inflammation risk among childbearing age Mexican-American women
Keyword(s): Maternal and Child Health, Latinos
Qualified on the content I am responsible for because: presented research was conducted by me as part of my dissertation work.
Any relevant financial relationships? No
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