Online Program

Clinical, Social and Genomic Factors Associated with Obesity at 12 Months of Age

Sunday, November 1, 2015

Sahel Hazrati, MPH, Inova Translational Medicine Institute, Falls Church, VA
Kathi Huddleston, PhD, RN, MSN, CNS, CCRC, Inova Translational Medicine Institute, Inova Health System, Falls Church, VA
Many genomic risk factors are associated with obesity. There are few prospective studies in infants, where genomic factors may have a more influential role. Over 1800 families from various races or ethnicities have been recruited in prenatal stage, in the longitudinal genomic study of “First 1000 Days of Life”, at Inova Translational Medicine Institute. 650 children had clinical and genomic data available at age 12 months. Whole genome sequencing was performed on blood. Weight for length at 12 months was calculated using WHO gender specific growth charts with the following definitions: overweight ≥85th, obese ≥95th, severely obese ≥99th percentiles.  A supervised genetic analysis was conducted using the SKAT for the association of rare variants (MAF<=0.1) with obesity. Gene-set level p-values were computed for 363 obesity related genes from the human obesity gene map. Chi-square and One-way ANOVA were used to test for association of clinical and social factors with obesity. Of the 650 infants, 31% were overweight, 20% obese and 13% severely obese. After adjusting for multiple testing with Bonferroni correction, only two genes were significant at the 0.1 level, namely, WT1 (P=0.0033) and CNR1 (P=0.090), for the severely obese group. None of the genes were significant after Bonferroni correction for the overweight or obese groups. Clinical and socials factors that were significantly associated (p<0.05) with being overweight and obese in all 3 groups were Hispanic origin, lower maternal education and any juice consumption at 12 months.

Learning Areas:

Chronic disease management and prevention
Diversity and culture
Public health biology

Learning Objectives:
Evaluate genomic, social and clinical predictors of obesity at 12 months

Keyword(s): Obesity, Genetics

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: Sahel Hazrati, MPH, was born in 1972 in Iran and immigrated to the United States in 2009. She has over 10 years of international experience in epidemiological studies, clinical research, survey design, data analysis and presentation. Her research and publications/presentations focused on obesity, diabetes, gestational diabetes, children’s media exposure and youth risky behavior. Currently, she is a PhD student and works as an epidemiologist at INOVA Fairfax Hospital, Translational Medicine Institute in Falls Church, Virginia.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.