Online Program

339222
Clinical trials of opioid pharmacotherapies in criminal justice system populations


Tuesday, November 3, 2015 : 11:10 a.m. - 11:30 a.m.

Joshua Lee, MD, MSc, Department of Population Health, Dept. Medicine, NYU School of Medicine, New York, NY
Despite the proven efficacy and community effectiveness of opioid medication therapies (methadone, buprenorphine, XR-naltrexone), few jail, prison, or community (CJS) populations access these treatments. NIH, in particular NIDA, have supported high-quality randomized trials
of MAT in CJS populations, which alongside international health services data, establish the rationale for more broadly implementing and disseminating these interventions. A review of the evidence will include: outcomes for HIV+ prisoners at re-entry linking buprenorphine uptake and improved HIV markers; buprenorphine vs. methadone NYC jail RCT; XR-NTX relapse prevention for persons leaving jails and among community-dwelling parolees and probationers; multiple RCT focused on the implementation of pre-release methadone maintenance for treatment of opioid dependence. Summary discussion will consider the practical barriers to MAT implementation and implications for overdose prevention, community addiction treatment, and chronic disease management.

Learning Areas:

Basic medical science applied in public health
Clinical medicine applied in public health
Ethics, professional and legal requirements
Implementation of health education strategies, interventions and programs
Protection of the public in relation to communicable diseases including prevention or control
Public health or related public policy

Learning Objectives:
Describe the rationale for MAT trials among CJS involved opioid dependent populations, consider the strength of evidence supporting the use of buprenorphine, methadone, and XRnaltrexone as pre-release interventions, and discuss the context of typical systems and policy barriers to wider CJS-MAT dissemination and implementation.

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am the PI of multiple NIH trials of opioid and alcohol pharmacotherapies among criminal justice and primary care populations. Our research agenda concerns expanding access and effective treatment options for these common addictive disorders.
Any relevant financial relationships? Yes

Name of Organization Clinical/Research Area Type of relationship
Alkermes, Inc. In-Kind Study Drug Employment (includes retainer)
Reckitt-Benkiser In-Kind Study Drug Employment (includes retainer)

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.