Background: The public health evidence supports that environmental factors in our homes, schools, and air that we breathe are associated with increased vulnerability in children and a worsening of common conditions that include asthma, autism, type 2 diabetes and obesity ( Woolf, Sibrizzi & Kirkland, 2016). The Children's Environmental Health Center of the Hudson Valley (CEHCHV) is an Academic/Practice partnership between New York Medical College and the Maria Fareri Children's Hospital. A specific aim of the CEHCHV is to address population health that is grounded in the evidence. Founded in 2008, this collaboration serves the Lower Hudson Valley of New York State. Our Center is fully integrated with an academic pediatric pulmonology and allergy division, with 9 outreach offices throughout the region. We are multi-disciplinary with physicians, nurse practitioner, nurses, social worker, respiratory therapists, researchers and public health community workers. Description: Healthy Child development is determined by many factors that include the neighborhood or environment where the child grows up and the exposure to environmental toxins (Landrigan, 2016).The Center focuses on educating communities, healthcare and public health professionals on the important relationships between the environment and health. We offer clinical consultations, perform research and advocate on the relationship between environmental toxicants and disease in children. Lessons Learned: Lower socio-economic and minority populations are at increased risk (Wolf,2016). There is a demonstrable need to expand this practice model nationally and internationally. Implications/Recommendations: Recent events in Flint, Michigan underscore the importance of such partnerships to promote a healthier nation and reduce inequities.