background: It is clear that using one substance alone is seldom the pattern of use. It is less clear, however, where electronic cigarette (EC) use fits into that pattern. We aimed to understand patterns of lifetime substance use, including EC and conventional cigarette (CC) use, among a community sample from North Florida. methods: At HealthStreet, a Community Health Worker based community engagement model at the University of Florida, participants report their lifetime use of EC, CC, and other illicit drugs. Latent class analysis was used to understand patterns of lifetime EC, CC, marijuana, club drug, hallucinogen, cocaine, heroin, and amphetamine use among the community sample. results: Of the 2268 HealthStreet members included in the analysis, 1374 (60.6%) were female and 1419 (62.6%) were Black. About 10% (n=241) of members had ever used ECs, and about half (n=1104) had ever used CCs. Latent class analysis revealed 4 classes of members. Class 1 (n=1297) was characterized by never substance use. Class 2 (n=367) was characterized by lifetime marijuana and CC use only, and Class 3 (n=497) was characterized by lifetime cocaine, marijuana and CC use. Class 4 (n=107) was characterized by lifetime poly-substance (EC, CC, and all 6 illicit drugs) use. discussion: We found four distinct patterns of combined EC, CC and illicit drug use. Findings suggest that population subgroups using illicit drugs commonly thought of as recreational such as marijuana and cocaine tend to also use CC, but not EC. Future research will focus on further characterizing EC and CC users.