Objectives: Clopidogrel is prescribed to prevent patients with coronary stents from developing potentially fatal blood clots. Though it is recommended that patients take clopidogrel for a year or longer, adherence is often poor. As part of an ongoing hybrid effectiveness-implementation study, we interviewed providers and patients at participating Veterans Health Administration (VHA) hospitals to better understand contextual factors and assess their experience with a clopidogrel adherence improvement strategy. Methods:The study intervention entailed clopidogrel brought to patients' bedsides before hospital discharge. Participants then received automated interactive-voice response (IVR) calls to remind them to place subsequent refills. We interviewed 41 cardiac catheterization laboratory providers and inpatient pharmacists from 16 sites at baseline, 6 and 12 months post-implementation. Patients (n=21) from six sites were interviewed at 2-3 months post study enrollment. We conducted descriptive qualitative analysis using the ATLAS.ti software. Results: Providers described participating in the study as a positive experience and “worth the effort.” Implementation barriers included lack of staff time and poor post-discharge communication between tertiary hospitals and primary care referral facilities regarding the need for continuous clopidogrel treatment. Patients expressed appreciation for the intervention. Providers and patients offered recommendations to improve the intervention for sequential roll-out at other sites, including: 1) standardizing the number of days supplied for refills; 2) obtaining more buy-in from pharmacy staff; and 3) implementing follow-up phone calls to patients to reinforce the information received at discharge. Conclusions: These interim findings have been used to make changes to improve the intervention and the implementation process across multiple VHA sites.