North Carolina ranks in the bottom 10% for preventive oral health services for children. Lack of fluoride in rural areas and reduced access to dental providers are indicative of oral health challenges in the state. The purpose of this study was to examine the relationship between childhood environmental factors indicative of NC and self-rated oral health status (SROH) among college students at a state university in NC. We conducted an online cross-sectional survey by recruiting a stratified random sample of undergraduate and graduate students. We performed logistic regression to calculate the odds ratios and 95% confidence intervals to model the association between environmental factors (residence in NC, residing in a rural area, lack of fluoride exposure) and SROH. We controlled for oral health self-efficacy, utilization and behaviors, previous extractions and demographics. Most students (n=282) resided in NC during childhood (63.5%); 27% in rural areas and 10% had no exposure to fluoridated water. In adjusted analyses, environmental factors were not associated with poor SROH. Brushing once per day or less had 3.25 times increased odds of poor SROH (95%CI=1.50-7.04). No dental visit in 2 or more years significantly increased odds of poor SROH by 144% and a previous tooth extraction was marginally significant with 144% increased odds. We found no significant association between environmental factors and poor SROH in this college community. However, poor oral health behaviors may reflect lack of utilization and education in childhood, suggesting that oral health campaigns and dental insurance should be implemented on college campuses.