Background: The role of climate in infectious disease (ID) dynamics may impact, directly or indirectly, pathogen interaction, viability, and human transmission. These changes may propagate outbreaks such as Influenza, Lyme disease, Zika, Ebola among others. Implications for occupational workers are successively diverse in exposure, protection and training processes. The National Institute of Environmental Health Sciences (NIEHS) Worker Training Program (WTP) acknowledged various training gaps and produced a Pathogen Safety Data (PSD) guide and training module. Course objectives highlight trusted PSD resources, hazard identification and risk assessment models, and infection control and prevention practices that potentially mitigate communicability of Bloodborne and other pathogens. The impact of PSD pilot training among healthcare and non-healthcare worker populations is demonstrated. Methods: Sixteen primary PSD resources were identified in the world-wide web. Strengths, limitations and best practices were reviewed and assembled into a PDF guidebook, PowerPoint segment, glossary and four case studies. Five, four-hour, pilot courses were conducted between June 2016 and May 2017, using participatory learning techniques. Post-test surveys and NIEHS progress reports were analyzed. Results: An enhanced perspective of hazardous properties, risk and safety provisions are expected among workers. Case studies contextualize PSD and occupational scenarios. Tailoring curricula for the audience breeds relevance, applicability and familiarity with ID jargon. Participatory learning techniques add-value to overall worker learning experience. Conclusions: As workers face ID hazards amidst changing climates and emerging pathogens, the NIEHS WTP PSD course empowers a broad-scope of workers to use reliable PSD resources and an integrated approach to ID response.