The intersection of opioid use, particularly via injecting, and HIV is well documented. In the United States, contracting HIV through injection drug use, either directly or via sexual contact with a person who injects drugs, accounts for more than one-third of estimated AIDS cases since the beginning of the epidemic, and 9% of estimated new infections. Untreated opioid use disorder is associated with increased risk of HIV transmission, interferes with antiretroviral treatment adherence, and impedes HIV viral suppression. The devastating outbreak of more than 180 HIV infections diagnosed in 2015 among persons injecting oxymorphone in rural southeastern Indiana is an example of the way in which injection drug use can be the primary driver of localized epidemics. This evidence-informed intervention operates at two levels by providing individual level treatment to the patient and creating systems level change within the clinic. The Dissemination of Evidence Informed Interventions initiative has funded the following clinics for implementation: University of Kentucky Bluegrass Cares Clinic in Lexington, KY, Centro Ararat FAITH Clinic in Ponce, PR, and MetroHealth in Cleveland, OH. These sites vary in terms of geographic location, patient populations, clinic structure, and experience prescribing buprenorphine. This presentation will share lessons learned from early phases of implementation at the three diverse implementation sites that have facilitated successful enrollment and retention in buprenorphine treatment, as well as integration of the intervention throughout the clinic system.