Suicide is a major public health issue in Colorado and in the U.S. Currently, suicide is the 7th leading cause of death in Colorado and the 10th leading cause of death nationally. Unfortunately, suicide prevention efforts continue to be under-funded and operate in silos, and often have a narrow focus on identification of those in crisis or in need of immediate intervention and treatment. In Colorado there are local, state and national partnerhsips underway to design, disseminate, and evaluate a comprehensive suicide prevention program with the goal of reducing suicide rates by 20 percent by 2024. Data-informed efforts will include both implementing selected and indicated best parctice interventions and ‘upstream’ strategies that aim to change life trajectories. When focusing on antecedent social and interpersonal risks, as well as individual-level factors, many of these efforts can serve more broadly as prevention for premature death from self-injury (e.g., drug overdose deaths) as well as prevention of problems such as intimate partner violence. Not typically considered “suicide prevention,” they reflect critical data reported by the National Violent Death Reporting System and other sources. This session will describe the development of the Colorado-National Collaborative (CNC), a group made up of Colorado and national leaders who are focusing on devising strategies and building the necessary partnerships involving state and local governmental agencies, health providers, including the Veterans Health Administration, the courts and criminal justice system, employers, and a diverse array of community participants to implement a comprehensive, collaborative, and integrated suicide prevention approach in Colorado. The session will discuss the background and formation of the CNC, and detail partnership development and the adoption of a unified strategy. The session will also discuss CNC priorities, leadership and partners,and the work devoted to creating a logic model as a guide for future efforts. The session will also describe a new data visualization tool, and tools developed to inventory current state efforts and partners. These, in turn, will serve as a basis for defining next steps and priorities in our unfolding process.