Background: Recent data from the West Virginia Cancer Registry highlights the complex, diverse nature of cancers in the state and the need for strategic efforts in early detection and prevention. Essential is the need for West Virginia primary care to have a more systematic, comprehensive approach to preventing and controlling cancer. Objective/Purpose: The West Virginia Program to Increase Colorectal Cancer Screening (WVPICCS) and the West Virginia Breast & Cervical Cancer Screening Program (WVBCCSP) are two major arms of a state-wide effort in comprehensive cancer prevention and control. Designed to better equip primary care with knowledge, skills, and abilities to sustain systems-level change, these interventions enhance health informatics technology (HIT) capacities in using electronic health records (EHR) data for cancer screening. Methods: WVPICCS, now in year three, and WVBCCSP, now in year one, use a cohort-based approach to collaborating with primary care systems to assess and strengthen HIT applications. Site-level trainings focus on: EHR data quality; enhanced use of EHR data for identification of at-risk patients; office flow redesign for data driven team-based care; and increased skills in using EHR data for patient and population health. Results: During 2017, there have been 176 practice facilitation contacts to 21 WVPICCS partnering clinics, including 38 EHR technical support sessions. Evaluation of year-one WVPICCS cohort data shows an increase in mean screening rates from 28% (baseline) to 51% after one year of implementation of evidence-based interventions coupled with HIT assistance. WVBCCSP has an established network of more than 160 screening providers and will leverage these long-term collaborations to implement this new approach. Discussion/Conclusions: WVPICCS and WVBCCSP are helping to remedy long-standing issues in using EHRs for cancer screening and prevention. A hands-on, collaborative approach to learning from and working with primary care is proving effective in increasing screening rates in a way which is sustainable and beneficial to health systems and patients served.