Background: Uptake of the human papillomavirus (HPV) vaccine has been abysmal in the U.S. and far below the Healthy People 2020 goal of 80% coverage among adolescents. There is incongruence of low HPV vaccination coverage with high HPV-associated disease, including cancer, in rural communities across the U.S. Interventional HPV vaccination study designs, such as randomized control trials, quasi-experimental studies, and pragmatic trials, focused on changing HPV vaccination-related outcomes are less common in rural communities. The purpose of this narrative review was to examine HPV vaccination intervention studies in the past 10 years in rural settings. Methods: Using systematic search criteria, PubMed, PsychINFO, CINAHL, and Web of Science were searched for studies relating to the implementation of HPV vaccination interventions in rural U.S. settings using a comprehensive timeframe of January 1987 – December 2017, with a specific focus on the past 10 years during vaccine availability. The search yielded 611 studies in total. Next, all intervention articles, which we defined as “moving beyond descriptive research and focusing on deliberate action at any level (i.e. individual, organizational, etc.),” were selected from the databases (n=54). Studies were included in the final analysis if they met the following criteria: (a) focused on HPV vaccination; (b) took place in a rural U.S. setting; and (c) allowed full article access. The articles were then analyzed for content based on study and intervention characteristics. Results: Our review of the literature identified 11 articles focused on HPV vaccination interventions in rural settings. This was a small proportion of the overall pool of studies. A focus on the unique characteristics of rural settings was unaccounted for in most of the articles. Commonalities and differences among the identified studies, scientific gaps, and recommendations to increase HPV vaccination interventional research in rural communities were identified to inform future intervention research. Conclusions: As compared to the broader HPV vaccination literature, interventions in rural settings are represented in a limited fashion and there are few intervention studies. Rural populations represent a key population in which to address low HPV vaccination uptake as well as prevention of HPV-associated cancers.