Problem statement: Latino immigrants are disproportionately impacted by the Substance Abuse, Violence, AIDS/HIV, and MEntal health (SAVAME) syndemic. Community Resilience (CR) is a novel asset-based approach to address social determinants of health in vulnerable populations. Our formative community-academic study sought to explore how a CR approach could be used to address the SAVAME syndemic among Latinos. Relevance: Findings will add to the limited evidence base regarding effective interventions targeting this syndemic. Methods: In-depth interviews were conducted with participants (N=10) and a facilitator of a CR training implemented by two Latino-serving Philadelphia-based organizations. Interviews queried after participants' experiences and reactions to the training, as well as their individual resilience and their ability to affect community resilience. Structured summaries of interview audio files were created based on key research questions. Summaries were reviewed systematically; major themes and qualitative assertions were derived and discussed by the analysis team. Results: Participants found the training relevant to their personal needs. They recognized their own resilience and described changes in how they perceive and approach adversity. Participants described utilizing tools they learned to make personal positive changes but felt more could be done to affect community-level resilience. Participants agreed that training resilient community leaders to be agents of change can help mobilize communities to address factors related to syndemic conditions. Conclusions: Cultivating resilience in immigrants can have positive effects on wellbeing. Integrating resilience in community-based interventions, especially among vulnerable communities, can be an effective tool to address the SAVAME syndemic and reduce Latinx health disparities.