Lung cancer is the leading cause of cancer deaths in men and women. It is estimated that over 222,500 individuals will receive a new diagnosis of lung cancer this year. African American men and women are more likely to develop lung cancer than Caucasians (1). The National Lung Cancer Screening Trial (NLST) published in 2011 demonstrated that patients who are high risk for lung cancer and undergo low-dose CT can reduce mortality from lung cancer by 20% (2). The USPSTF thus recommended lung cancer screening for patients 55-80 years old and with a smoking history of 30 pack-years who have smoked in the past 15 years (3). Although the risk and overall mortality from lung cancer is higher for African-American individuals, those who undergo lung screening have a decreased mortality from lung cancer in comparison to other races (4). Despite this, adoption of these screening criteria leads to an exclusion of some African Americans who could benefit from lung screening as they generally have a lower than 30 pack-years smoking history (6). Research suggests that the higher age and 30 pack-year smoking history criteria do not accommodate African American’s high risk of developing lung cancer at earlier ages with a lower pack-year history. The Prostate, Lung, Colorectal, and Ovarian Cancer Screening (PLCO) model allows for individualized risk assessment for lung cancer that includes race and education level, a surrogate for socioeconomic status, in addition to age and smoking history. This study reviews individual risk factors in patients enrolled in the VLSP from August 2016 to May 2017 to determine how specific risk factors impact lung cancer screening eligibility and risk in African Americans in comparison to other races. We hypothesize that the risk of lung cancer will be higher in African Americans in comparison to the total population of patients in the VLSP and that African Americans will have lower pack years in comparison to the total population in the VLSP. Project was IRB approved #170913. Data from Vanderbilt Lung Screening Program (VLSP) was collected. PLCO risk calculation was performed to include potential risk factors of race, age, smoking history, education level, family history of lung cancer, personal history of any cancer and history of COPD. This data was then stratified by race (African Americans, Caucasians, Asians and Hispanics). There were a total of 434 patients enrolled in the VLSP with PLCO risk calculated (375 Caucasian, 52 African Americans, 6 Asians and 2 Hispanics). Analysis and comparisons showed that African Americans had lower average pack years (46) in comparison to Caucasians (49), lower average educational level (2.87) in comparison to Caucasians (3.84) and lower percentage of African Americans (11%) have a personal history of any cancer in comparison to Caucasians (25%). Furthermore, analysis showed that African Americans had a higher percentage of current smokers, more likely to have COPD, and a higher average PLCO risk calculation at 78%, 27%, and 8.4, respectively, in comparison to Caucasians, 63%, 21%, and 5.3. African Americans in the VLSP have a greater overall risk of developing lung cancer as defined by the PLCO model than Caucasians, despite being of similar age and smoking less. This emphasizes the need for dedicated outreach to our African American population to increase enrollment in a lung screening program. Additionally, further research is needed to determine if eligibility criteria should be individualized with models including race and other risk factors rather than being limited to age and smoking history. Limitations observed were with making comparisons to other races (Asians and Hispanics) due to very small sample size.