West Virginia ranks 1st and 2nd nationally in the prevalence of hypertension (42.7%) and diabetes (14.5%). Patients with type 2 diabetes mellitus (T2DM) are distressed over physical and psychological burden of disease self-management. Hence, this feasibility study explored the relationship between diabetes distress, glycemic control, and blood pressure among T2DM adults who participated in a randomized controlled trial (RCT) comparing a 12-week diabetes and hypertension self-management program (DHSMP) to a wait-listed control group. Trained Health Coaches implemented the lifestyle program in a church setting using an evidence-based curriculum. Twenty adults with T2DM and hypertension (n=10 per group; mean age 55 ± 9.64 years; mean HbA1c 7.8 ± 2.24) completed baseline, 12- and 24-week assessments. Diabetes distress was measured by using a validated Diabetes Distress Survey (17-item Likert scale; four sub-scales of emotional burden, physician related burden, regimen related burden, and interpersonal distress). Changes in diabetes distress were compared using waterfall plots; Spearman’s correlation was used to evaluate association between diabetes distress, HbA1c and blood pressure. Overall, 70% of the participants reported decrease in total distress score after the program (regimen related distress (80%); Emotional burden (50%); Interpersonal distress (50%). In general, diabetes distress reduced among participants with HbA1c ≤ 8% (r=0.28, p=0.4), and systolic/diastolic blood pressure ≤140/80 mm Hg (r=0.045, P=0.18). Findings suggest that lifestyle self-management programs have the potential to reduce diabetes distress among patients. In addition, it can provide valuable information to help health care providers and patients identify interventions and coping strategies to improve diabetes outcomes.