In March of 2020, Ohio’s health agencies initiated two population-based COVID-19 tracking studies to examine symptoms, prevention, employment changes, and socioeconomics related to the pandemic. Research started April 2020 and continues through June 30, 2022. The samples consist of: (1) Respondents from the 2019 Ohio Medicaid Assessment Survey (OMAS), which examines healthcare access and use, insurance status, health behavioral risks, self-rated health status, and health demographics (OCS); and (2) respondents of Ohio Medicaid’s Community Engagement 1115 Waiver and CFC populations (MCS). Samples were selected to provide researchers with baseline information prior to the pandemic’s arrival in Ohio; the intention being to examine Ohio’s general and Medicaid populations pre-, during-, and post-pandemic (once the pandemic recedes). Thus far, the results of the OCS and MCS indicate that: (1) prevention practices increased as the pandemic spread over time; (2) select COVID symptoms were not as prevalent as researchers initially hypothesized and were clustered in certain populations and geographic locations; (3) employment was impacted, but less than expected; (4) lower socioeconomic populations reported more mental distress and economic-associated stressors; (5) pandemic fatigue has set into Ohio’s population; and (6) vaccine hesitancy has decreased, but has stalled at a higher than expected rate. The OCS and MCS continue in the field with the intent of examining the impacts of the pandemic on the population’s health, mental health, socioeconomic status (particularly employment and housing), and vaccine adoption. Both the OCS and MCS were reviewed and classified as work-for-hire by The Ohio State University IRB.