Background: When Covid-19 vaccines first became available in early 2021, many individuals faced access barriers to vaccination. We describe the implementation of the Mobile Health Clinic (MHC) framework to deliver Covid-19 vaccines to underserved communities in South Carolina.

Methods: Prisma Health implemented a novel MHC program to reach and vaccinate high-risk communities in South Carolina. We examined rates of first, second, and booster doses of Covid-19 over a 12-month period beginning in February 2021.

Results: Prisma Health’s five MHCs made 272 visits to 153 unique sites. Site visits included churches (N=69), K-12 schools (N=48), universities (N=16), homeless shelters (N=6), and other sites (N=80). MHCs distributed 12,102 COVID-19 vaccines among 8,545 individuals. Among those vaccinated via the MHC, the median age was 42 years, and the majority were female (50.5%), Black (44.0%: White/Hispanic: 30.7%/10.3%), and the uninsured rate was 44.2%. In total, 4,344 (50.8%) individuals received the complete primary series (1-dose J&J or 2-dose mRNA vaccine), 2,883 (33.7%) received one-dose of the primary mRNA series (1^st dose: 2,548, 2^nd dose 335), and 1,318 (15.4%) received an mRNA booster dose. Among 5,920 individuals receiving their first dose of the mRNA vaccine series (Pfizer or Moderna), 3,360 (56.8%) returned to an MHC to receive their second dose.

Conclusion: MHC substantially increased Covid-19 vaccination rates in the Upstate and Midlands regions of South Carolina. Uninsured individuals and individuals of color were substantially more likely to utilize MHC services for vaccination, demonstrating the utility of MHC in reducing health disparities perpetuated by the Covid-19 pandemic.